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Nephrol Dial Transplant (2000) 15: 1450-1452
© 2000 European Renal Association-European Dialysis and Transplant Association

Case Reports

Hypercalcaemia and acute interstitial nephritis associated with omeprazole therapy

Catherine A. M. Wall1, Eoin F. Gaffney2 and George J. Mellotte1,

1 Department of Renal Medicine, Adelaide and Meath Hospitals, Dublin and 2 Department of Histopathology, St James' Hospital, Dublin, Ireland

Keywords: acute interstitial nephritis; acute renal failure; hypercalcaemia; omeprazole



   Introduction
 
Hypercalcaemia is a biochemical abnormality frequently encountered in clinical practice. Laboratory and radiological investigations appropriate to the clinical setting can usually determine the cause of this abnormality. Hypercalcaemia in the setting of acute renal failure (ARF) is not uncommon but is typically associated with rhabdomyolysis [1] and resolves spontaneously as renal function recovers. We report the case of a patient who developed hypercalcaemia several weeks after recovering from an episode of ARF. Despite extensive investigations, we were unable to find a cause for the patient's hypercalcaemia. A renal biopsy performed to investigate persistent mild renal dysfunction finally revealed the reason for the patient's renal impairment. We speculate that the renal lesion was also the cause of the associated hypercalcaemia.



   Case
 
A 31-year-old female was admitted to a local maternity hospital in March 1998 at 35 weeks gestation complaining of severe nausea and vomiting that had become marked in the . . . [Full Text of this Article]



   Discussion
 


   Notes
 


   References
 

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