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Nephrol Dial Transplant (2000) 15: 1384-1387
© 2000 European Renal Association-European Dialysis and Transplant Association

G-protein ß3-subunit C825T genotype and nephropathy in diabetes mellitus

Joachim Beige1, Jens Ringel1, Armin Distler1 and Arya M. Sharma2,

1 Department of Internal Medicine, Division of Endocrinology and Nephrology, Universitätsklinikum Benjamin Franklin, Free University of Berlin, Berlin, Germany and 2 Department of Nephrology, Hypertension and Genetics, Franz-Volhard-Klinik, Humboldt-University, Berlin, Germany

Background. Recent studies have identified a novel polymorphism (C825T) of the gene encoding the ß3 subunit of heterotrimeric G proteins (Gß3) which is associated with enhanced activation of G-proteins and appears to be more common in hypertensive patients and possibly contributes to decreased kidney allograft survival.

Methods. In the present study we examined the relationship between this genetic variant, type 1 and type 2 diabetes and renal complications of diabetes in 1008 Caucasian patients recruited from an outpatient diabetes clinic and four dialysis centres. We also studied 1940 healthy controls.

Results. After multivariate adjustment and in univariate statistics, the Gß3 825TT genotype was not associated with a significantly enhanced risk of diabetes or renal complications.

Conclusions. These findings indicate that the Gß3 825T allele apparently does not contribute to the development of diabetes or associated renal complications in patients with type 1 or type 2 diabetes mellitus.

Keywords: diabetic nephropathy; Gß3; G-proteins; genetics; HbA1C; polymorphism

Correspondence and offprint requests to: Professor Dr Arya M. Sharma, Medizinische Klinik IV, Klinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, D-12200 Berlin, Germany.


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