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Nephrol Dial Transplant (2000) 15: 1238-1241
© 2000 European Renal Association-European Dialysis and Transplant Association

Case Reports

A case of anti-glomerular basement membrane glomerulonephritis superimposed on membranous nephropathy

Takashi Sano1, Kouju Kamata1, Hidekazu Shigematsu2 and Yutaka Kobayashi1,

1 Department of Medicine, School of Medicine, Kitasato University, Sagamihara City, and 2 School of Medicine, Shinshu University, Matsumoto City, Japan

Keywords: anti-glomerular basement membrane glomerulonephritis; crescentic glomerulonephritis; membranous nephropathy



   Introduction
 
There are two major mechanisms of immunological injury to the glomerulus. The first type is characterized by glomerular deposition of immune complexes, which occurs in the nephropathy of systemic lupus erythematosus, membranous nephropathy, etc. In the second variety, injury is mediated by anti-glomerular basement membrane (anti-GBM) antibody. Anti-GBM antibody mediated injury is most frequently characterized by crescentic glomerulonephritis and rapid deterioration of renal function with or without pulmonary haemorrhage. Simultaneous occurrence of membranous nephropathy and anti-GBM glomerulonephritis has been rarely reported. We report the clinical and histological features of a patient with anti-GBM glomerulonephritis superimposed on membranous nephropathy.



   Case
 
A 54-year-old woman was admitted to Kitasato University Hospital in June 1993 because of gross haematuria, . . . [Full Text of this Article]



   Discussion
 


   Notes
 


   References
 

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