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Nephrol Dial Transplant (2000) 15: 1235-1237
© 2000 European Renal Association-European Dialysis and Transplant Association

Case Reports

Primary Epstein–Barr virus infection and recurrent type I membranoproliferative glomerulonephritis after renal transplantation

Margret B. Andresdottir1,, Karel J. M. Assmann2, Luuk B. Hilbrands1 and Jack F. M. Wetzels1

1 Department of Internal Medicine, Division of Nephrology, and 2 Department of Pathology, University Hospital Nijmegen, The Netherlands

Keywords: Epstein–Barr virus; membranoproliferative glomerulonephritis; transplantation



   Introduction
 
Most patients with type I membranoproliferative glomerulonephritis (MPGN) progress toward end-stage renal disease, and after cadaveric transplantation the disease will recur in up to 50% of the patients [1]. In recent years an association between hepatitis C virus infection and the development of type I MPGN has been suggested [2,3]. We report a patient with type I MPGN who developed a recurrence of his disease within 7 months after transplantation. The development of the glomerulonephritis coincided with the onset of a primary Epstein–Barr virus (EBV) infection. A graft biopsy demonstrated the presence of EBV in the podocytes, suggesting that the EBV infection may have triggered the glomerular disease.



   Case
 
Our patient, a Caucasian boy, developed proteinuria and haematuria in 1993 at the age of 16 years. A renal biopsy was performed in 1994, and disclosed a type I MPGN. At the time of the biopsy . . . [Full Text of this Article]



   Discussion
 


   Acknowledgments
 


   Notes
 


   References
 

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