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Nephrol Dial Transplant (2000) 15: 994-999
© 2000 European Renal Association-European Dialysis and Transplant Association

Increased blood levels of platelet-activating factor in insulin-dependent diabetic patients with microalbuminuria

Paolo Cavallo-Perin1, Enrico Lupia1, Gabriella Gruden1, Carla Olivetti1, Antonella De Martino, Maurizio Cassader1, Daniela Furlani1, Luigi Servillo2, Lucro Quagliuolo2, Eugenio Iorio2, Marcia Rosario Boccellino2, Guiseppe Montrucchio1 and Giovanni Camussi1,

1 Department of Internal Medicine and Department of Clinical Pathophysiology, University of Turin and 2 Department of Biochemistry and Biophysics, II University of Neaples, Italy

Background. Platelet-activating factor (PAF), a phospholipid mediator of inflammation, may induce an enhanced size- and charge-dependent glomerular permeability in experimental animals. Studies on the role of PAF in enhanced glomerular permeability in the early phase of diabetic nephropathy are still lacking.

Methods. We evaluated the intravascular levels of PAF and its main catabolic enzyme, the PAF-specific plasma acetyl-hydrolase (PAF-AH), in basal conditions and after exercise, in normo- or micro-albuminuric insulin-dependent diabetic (IDD) patients and in normal subjects.

Results. The results obtained indicate that the concentration of PAF in whole blood was significantly enhanced in basal conditions, during and after exercise in all microalbuminuric IDD patients, but not in normoalbuminuric IDD or in control subjects. The increased concentration of PAF did not correlate with changes in the activity of PAF-AH, suggesting an enhanced production rather than a decreased catabolism of PAF.

Conclusions. These results indicate an association between increased production of PAF and enhanced glomerular permeability in microalbuminuric IDD patients.

Keywords: PAF; diabetes; microalbuminuria; exercise

Correspondence and offprint requests to: G. Camussi, Laboratorio di Immunopatologia Renale, Cattedra di Nefrologia, Dipartimento di Medicina Interna, Corso Dogliotti, 14, I-10126 Torino, Italy.


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