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Nephrol Dial Transplant (2000) 15: 940-942
© 2000 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

ACTH revisited—potential implications for patients with renal disease

Anna-Lena Berg1 and Margret Arnadottir2,

1 Department of Nephrology, University Hospital, Lund, Sweden and 2 Department of Internal Medicine, National University Hospital, Reykjavik, Iceland

Introduction

Adrenocorticotrophic hormone (ACTH) facilitates the synthesis of adrenal glucocorticoids by maintaining the enzymes that control the side-chain cleavage of cholesterol, the rate-limiting step in the biosynthesis of steroids 1]. Thus, ACTH is involved in the control of adrenal lipid metabolism. Recent studies have revealed that treatment with ACTH in pharmacological dosage also influences plasma lipoprotein metabolism. This applies to both healthy individuals [2–4] and patients with different types of renal disease [5–7]. Moreover, the results of one of these recent studies suggest that treatment with ACTH has beneficial effects on the glomerular function of patients with idiopathic membranous nephropathy [7].

Effects of ACTH on plasma lipoprotein metabolism in healthy individuals

Short-term administration of ACTH to healthy individuals resulted in a rapid and pronounced reduction in the plasma cholesterol concentration [2. . . [Full Text of this Article]

Effects of ACTH on plasma lipoprotein pattern in patients with renal disease

Potential benefits of ACTH treatment in nephrology

Future work

Notes

References


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