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Nephrol Dial Transplant (2000) 15: 922-923
© 2000 European Renal Association-European Dialysis and Transplant Association

Letters

The patient with over 100 relapses of minimal change nephrotic syndrome: prolonged complete remission after chlorambucil treatment

Agustín Carreño, Enrique Morales, Beatriz Domínguez-Gil, Juan Carlos Herrero, Milagros Ortiz, Ester González and Manuel Praga

Servicio de Nefrología, Hospital 12 de Octubre, Madrid, Spain

Sir,

Minimal change disease accounts for more than 80% of the cases of idiopathic nephrotic syndrome in children. Several studies have demonstrated that more than 90% of patients show a complete disappearance of proteinuria after 6–12 weeks of steroid treatment [1]. However, a considerable proportion of patients, reaching more than 75% in some series, experiences relapses of nephrotic syndrome [2]; cyclophosphamide or chlorambucil treatment, usually administered for 6–12 weeks, leads to prolonged steroid-free remission in most children with frequently relapsing minimal change disease [3,4]. Here we report the exceptional clinical course of a patient that experienced more than . . . [Full Text of this Article]

Case.

Comment.

References


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