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Nephrol Dial Transplant (2000) 15: 758-760
© 2000 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

The role of the cardiac endothelin system in heart failure

Oliver Zolk and Michael Böhm

Klinik III für Innere Medizin, Universität zu Köln, Köln, Germany

Introduction

Since the isolation and identification of endothelins as very important vasoconstrictor peptides in 1988, clinical and experimental evidence suggests that endothelins play an important role in cardiac and vascular pathology associated with heart failure. Because of the frequency of heart failure in end-stage renal disease, this issue is definitely also of interest to the clinical nephrologist.

Though secreted predominantly abluminally by endothelial cells, plasma concentrations of endothelin-1 ET-1 are increased two to threefold in patients with heart failure irrespective of aetiology [1]. As with noradrenaline, plasma levels of ET-1 and big endothelin-1, the inactive precursor of ET-1, are of prognostic significance, predicting worsening heart failure, need for hospitalization, and death [2]. Plasma endothelin is correlated closely to the . . . [Full Text of this Article]

Action of endothelin in the heart

Regulation of the myocardial endothelin system in the failing heart

Conclusions and perspectives

Acknowledgments

Notes

References


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