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Nephrol Dial Transplant (2000) 15: 715-716
© 2000 European Renal Association-European Dialysis and Transplant Association

Case Report

Baclofen unerotoxicity in a chronic haemodialysis patient

Nader Bassilios, Vincent Launay-Vacher, Lucile Mercadal and Gilbert Deray

Department of Nephrology, Pitié Salpêtrière Hospital, Paris, France

Keywords: baclofen; encephalopathy; neurotoxicity



   Introduction
 
Baclofen is the ß-({rho}-chlorphenyl) derivative of the neurotransmitter gamma-amminobutyric acid (GABA). This centrally acting GABA agonist represents the elective pharmacotherapy for spasticity of spinal cord origin [1]. So far, few cases of baclofen-associated neurological toxicity have been reported in patients with renal insufficiency treated for severe hiccups; all had, however, received high doses . . . [Full Text of this Article]



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V.-C. Wu, S.-L. Lin, S.-M. Lin, and C.-C. Fang
Treatment of baclofen overdose by haemodialysis: a pharmacokinetic study
Nephrol. Dial. Transplant., February 1, 2005; 20(2): 441 - 443.
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