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Nephrol Dial Transplant (2000) 15: 412-414
© 2000 European Renal Association-European Dialysis and Transplant Association

Case Reports

Steroid-responsive nephrotic syndrome with minimal-change disease and IgA deposits in a HIV-infected patient

Evangelina Boix1, Francisco Rivera2, Carmen-María Gil1, Javier Pérez-Contreras1 and Jesús Olivares1

2 Servicio de Nefrología, Hospital General Universitario de Alicante and 1 Departamento de Medicina Clínica, Facultad de Medicina, Universidad Miguel Hernandez, Elche, Spain

Correspondence and offprint requests to: Dr F. Rivera, Servicio de Nefrología, Hospital General Universitario de Alicante, c/ Pintor Baeza, s/n. E-03010 Alicante, Spain.

Keywords: human immunodeficiency virus; IgA nephropathy; steroid-responsive nephrotic syndrome



   Introduction
 
Several types of glomerulopathy have been described in patients with HIV infection. Although HIV-associated nephropathy, namely `focal collapsing glomerulosclerosis' and related mesangiopathies, has been considered to be the most specific renal lesion, other immune-mediated renal diseases, such as membranous nephropathy, membranoproliferative glomerulonephritis, lupus-like nephritis and haemolytic–uraemic syndrome can be found in HIV-positive patients [1].

The association of minimal-change disease with nephrotic syndrome in HIV-infected patients has been described previously [1,2]. However, mesangial IgA nephropathy has also been reported [3]. In both situations the relationship between HIV infection and glomerular damage is not coincidental because viral products play a direct role in HIV-related renal diseases [4,5. . . [Full Text of this Article]



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P. L. Kimmel, L. Barisoni, and J. B. Kopp
Pathogenesis and Treatment of HIV-Associated Renal Diseases: Lessons from Clinical and Animal Studies, Molecular Pathologic Correlations, and Genetic Investigations
Ann Intern Med, August 5, 2003; 139(3): 214 - 226.
[Abstract] [Full Text] [PDF]