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Nephrol Dial Transplant (2000) 15: 235-238
© 2000 European Renal Association-European Dialysis and Transplant Association

Preliminary Report

Dextran sulphate cellulose columns for the treatment of nephrotic syndrome due to inactive lupus nephritis

Shoichiro Daimon1, Tsutomu Saga1, Miho Nakayama1, Yumi Nomura2, Hajime Chikaki2, Kazushi Dan2 and Ichiro Koni3

1 Department of Internal Medicine, 2 Division of Blood Purification, Maizuru Kyosai Hospital, Maizuru and 3 The Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan

Correspondence and offprint requests to: Dr Shoichiro Daimon, Department of Internal Medicine, Maizuru Kyosai Hospital, Hama 1035, Maizuru 625-8585, Kyoto, Japan.

Keywords: dextran sulphate cellulose column; nephrotic syndrome; systemic lupus erythematosus



   Introduction
 
The kidney is one of the major target organs of systemic lupus erythematosus (SLE). Although in recent years, the advent of immunosuppressive therapy has contributed to the prevention of renal functional deterioration in patients with SLE [1–3], diffuse proliferative lupus nephritis (DPLN), a frequent form of lupus nephritis, has a poor prognosis and a refractory nephrotic state frequently develops. In recent years, low-density lipoprotein apheresis (LDL-A) using dextran sulphate cellulose columns (DSCC) has been reported to be an effective tool for the treatment of some types of steroid-resistant nephrotic syndrome due to focal glomerular sclerosis, minimal change nephrotic syndrome or membranous nephropathy [4,5]. Because of its negatively charged characteristics, DSCC also has a high affinity to anti-DNA antibodies, and adsorption of anti-DNA antibodies (DNA-A) using DSCC has been adopted for the treatment of active lupus nephritis [6]. The difference between . . . [Full Text of this Article]



   Case report
 


   Discussion
 


   References
 

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