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Nephrol Dial Transplant (2000) 15: 1909-1910
© 2000 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Degranulation of polymorphonuclear leukocytes by dialysis membranes—the mystery clears up?

Sabine Schmaldienst and Walter H. Hörl

Division of Nephrology, Department of Medicine, University of Vienna, Vienna, Austria

Introduction

Degranulation of polymorphonuclear leukocytes (PMN) occurs during extracorporeal circulation. In patients undergoing regular haemodialysis treatment PMN degranulation has been used as one of several markers for membrane bioincompatibility [1]. In the past, it has been thought that the release of components from PMN granules follows the activation of the complement system in a time and membrane material dependent manner. It became clear, however, that complement activation and PMN degranulation observed during haemodialysis therapy are independent activation processes [1,2]. Cheung et al. [3] performed in vitro dialysis . . . [Full Text of this Article]

What are the intracellular signals for PMN degranulation during haemodialysis?

Inhibition of PMN degranulation by newly described proteins

Conclusion

Notes

References


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 J. Am. Soc. Nephrol.Home page
W. H. Horl
Hemodialysis Membranes: Interleukins, Biocompatibility, and Middle Molecules
J. Am. Soc. Nephrol., January 1, 2002; 13(90001): S62 - 71.
[Abstract] [Full Text] [PDF]