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Nephrol Dial Transplant (2000) 15: 1525-1528
© 2000 European Renal Association-European Dialysis and Transplant Association

Invited Comment

End-stage renal disease and erectile dysfunction. Is there any hope?

Waqar Ayub and Simon Fletcher

Renal Unit, Walsgrave Hospital NHS Trust, Coventry, UK

Keywords: end-stage renal disease; erectile dysfunction; pathophysiology

Introduction

A common problem that remains difficult to diagnose and treat in patients with chronic renal failure (CRF) is sexual dysfunction. Prevalence estimates of sexual dysfunction range from 9% in predialysis to 70% in dialysis patients of either sex [1,2]. The presence of erectile dysfunction ranges between 21 and 43% among dialysis and transplant patients and this prevalence has remained the same since the 1970s [3]. The causes of erectile dysfunction are frequently combinations of both organic and psychological factors. We review the pathogenesis, investigations, and treatment currently available for erectile dysfunction.

Pathophysiology of erectile dysfunction

Numerous sexual stimuli are processed by the brain and transmitted to the penis by parasympathetic impulses that pass through the nervi erigentes to the penis. This results in vasodilatation of the arteries, relaxation of the smooth layer, and compression of the veins against the rigid tunica albuginea, thus allowing blood to build up . . . [Full Text of this Article]

Assessment of sexual dysfunction

Management

Oral

Sildenafil (Viagra)
Yohimbine hydrochloride
Other drugs
Intraurethral

Alprostadil (prostaglandin E1)
Intracavernosal

Alprostadil (prostaglandin E1)
Vacuum devices
Penile prostheses
Conclusion

Notes

References


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This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
S. Turk, G. Karalezli, H. Z. Tonbul, M. Yildiz, L. Altintepe, A. Yildiz, and M. Yeksan
Erectile dysfunction and the effects of sildenafil treatment in patients on haemodialysis and continuous ambulatory peritoneal dialysis
Nephrol. Dial. Transplant., September 1, 2001; 16(9): 1818 - 1822.
[Abstract] [Full Text] [PDF]