Nephrol Dial Transplant (2000) 15: 1512-1514
© 2000 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
Pastis and hypertensionwhat is the molecular basis?
Division of Nephrology/Hypertension, University Hospital of Berne, Berne, Switzerland
Glycyrrhiza glabra
The therapeutic properties of Glycyrrhiza glabra were already known by Egyptians, Greeks, and Romans in antiquity [1]. They used extracts from this plant for a diversity of ailments and as a sweetener. In the modern society it is found in drinks such as Belgian beers, Ouzo, Pernod or Pastis brands. Many chewing gums contain glycyrrhetinic acid. The rationale for adding glycyrrhetinic acid, the active ingredient of liquorice, to chewing gums is the observation that, contrary to glucose, liquorice does not promote bacterial growth and adherence of cariogenic bacteria [2]. In addition liquorice is often added to confectionery. The discovery of the value of liquorice previously marketed as carbenoxolone, an oleandane derivative of glycyrrhetinic acid in the treatment of peptic ulcer allowed researchers to establish its adverse effect on salt and water metabolism.
Clinical features and erroneous interpretation
Patients with excessive ingestion of liquorice present with hypokalaemic
Mechanism of renal sodium retention and potassium loss induced by liquorice
11ß-HSD isoenzymes
Health hazards of liquorice
Acknowledgments
Notes
References
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