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Nephrol Dial Transplant (2000) 15: 1506-1509
© 2000 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Is there a role for locally produced complement in renal disease?

Mohamed R. Daha and Cees van Kooten

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands

Introduction

It has been shown that complement is a major mediator system in the pathogenesis of several, especially immune-complex-mediated, kidney diseases. The major site of synthesis of complement components is the liver; however, several studies indicate that extrahepatic production of complement components can be substantial. For the first subcomponent of complement C1q, it is believed that the production occurs primarily at extrahepatic sites, most probably by macrophage-like cells. Other cells that have been implicated in complement production are endothelial cells, epithelial cells, many kidney-, skin-, brain- and synovial-cells [1]. One of the main questions is: What the function is of locally produced complement proteins?

Expression of complement in the kidney

Depositions of immunoglobulins together with complement components are frequently encountered in glomeruli of diseased kidneys. The question is, however, whether these complement proteins are derived from the circulation and thus mainly synthesized by hepatocytes or whether these complement . . . [Full Text of this Article]

Is there a role for locally produced complement in the kidney?

Concluding remarks

Notes

References


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