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Nephrol Dial Transplant (2000) 15: 1504-1506
© 2000 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Macula densa signalling—a potential role of cyclooxygenase-2 (COX-2)?

Raymond C. Harris

George M. O'Brien Kidney and Urologic Diseases Center, and Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

Introduction

Prostaglandins are mediators of vascular tone and salt and water homeostasis in the mammalian kidney; their regulation of glomerular haemodynamics and distal nephron function has been well described. Renin production and release is also known to be mediated by prostaglandins generated by afferent arteriole and by prostaglandin-dependent signalling from the macula densa [1].

There are two separate gene products with cyclo-oxygenase activity, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). The gene for COX-1, the constitutive prostaglandin G2/H2, encodes a 2.7–2.9 kb transcript, while the gene for COX-2, the ‘inducible’ prostaglandin G2/H2 synthase, encodes a 4.2–4.5 kb transcript, which increases in response to inflammatory or mitogenic stimuli. In the kidney, constitutive prostaglandin G2/H2 synthase (COX-1) has been localized to mesangial cells, arteriolar endothelial cells, parietal epithelial cells of Bowman's capsule and . . . [Full Text of this Article]

What is the expression of COX-2 in the kidney?

Is there a role for COX-2 in regulating renin expression and release?

Do components of the renin–angiotensin–aldosterone system modulate COX-2 expression?

What is the pattern of COX-2 expression in human kidney?

Conclusions

Acknowledgments

Notes

References


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