Nephrol Dial Transplant (2000) 15: 34-42
© 2000 European Renal Association-European Dialysis and Transplant Association
Hypertriglyceridaemia and hyperuricaemia are risk factors for progression of IgA nephropathy
Department of Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland
Correspondence and offprint requests to: Jaana Syrjänen MD, Medical School, University of Tampere, PO Box 607, FIN-33101 Tampere, Finland.
Background. The prognosis of IgA nephropathy (IgAN) is variable and about 10–20% of patients progress to end-stage renal disease (ESRD) in 10 years. Hypertension, proteinuria and renal insufficiency at the time of diagnosis are risk factors associated with poor prognosis. Lipid abnormalities may have a role in the progression of glomerulonephritides, and glomerulosclerosis and atherosclerosis may have similar pathophysiological mechanisms. We therefore evaluated factors associated with cardiovascular diseases, especially hypercholesterolaemia, hypertriglyceridaemia, and hyperuricaemia, as predictors of the progression of IgAN.
Methods. A total of 223 patients with IgAN (141 men, 82 women; median age 41 years, range 8–78 years) were studied. The following parameters were recorded at the time of renal biopsy: presence of hypertension or diabetes, smoking habits, body mass index (BMI), serum creatinine, total and HDL-cholesterol, triglycerides, and urate and 24-h urinary protein excretion. The patients were followed up for 0.2–17 years (median 10 years) with respect to progression of renal disease defined as elevation of serum creatinine above 125 µmol/l in men or 105 µmol/l in women, and over 20% elevation from baseline.
Results. Forty-one patients (18%) showed progression. Hypertriglyceridaemia and hyperuricaemia were significantly more common at the time of renal biopsy in patients with progressive than in those with stable disease. In patients with normal renal function at the time of diagnosis initial hypertriglyceridaemia, hyperuricaemia, hypertension and proteinuria were independent risk factors for progression of IgAN in the Cox regression hazard model.
Conclusions. Our results show that hypertriglyceridaemia and hyperuricaemia at the time of diagnosis are important, previously underestimated predictors of poor outcome in IgAN, although causality between these factors and progression cannot be inferred from the present study.
Keywords: glomerulonephritis; hypercholesterolaemia; hyperlipidaemia; hypertriglyceridaemia; IgA nephropathy; uric acid
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. Yamamoto, Y. Nagasawa, T. Shoji, K. Inoue, T. Uehata, T. Kaneko, T. Okada, A. Yamauchi, Y. Tsubakihara, E. Imai, et al. A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN) Nephrol. Dial. Transplant., December 1, 2009; 24(12): 3686 - 3694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Coppo and J. Feehally Is progression of IgA nephropathy conditioned by genes regulating atherosclerotic damage? Nephrol. Dial. Transplant., December 1, 2009; 24(12): 3573 - 3575. [Full Text] [PDF]
|
|
|
|
|
|
J. T. Park, D. K. Kim, T. I. Chang, H. W. Kim, J. H. Chang, S. Y. Park, E. Kim, S.-W. Kang, D.-S. Han, and T.-H. Yoo Uric acid is associated with the rate of residual renal function decline in peritoneal dialysis patients Nephrol. Dial. Transplant., November 1, 2009; 24(11): 3520 - 3525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chen, W. Chen, H. Wang, X. Dong, Q. Liu, H. Mao, J. Tan, J. Lin, F. Zhou, N. Luo, et al. Prevalence and risk factors associated with chronic kidney disease in an adult population from southern China Nephrol. Dial. Transplant., April 1, 2009; 24(4): 1205 - 1212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Avram and E. Krishnan Hyperuricaemia--where nephrology meets rheumatology Rheumatology, July 1, 2008; 47(7): 960 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. G. Sanchez-Lozada, E. Tapia, P. Bautista-Garcia, V. Soto, C. Avila-Casado, I. P. Vega-Campos, T. Nakagawa, L. Zhao, M. Franco, and R. J. Johnson Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome Am J Physiol Renal Physiol, April 1, 2008; 294(4): F710 - F718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kaartinen, J. Syrjanen, I. Porsti, A. Harmoinen, A. Pasternack, H. Huhtala, O. Niemela, and J. Mustonen Insulin resistance and the progression of IgA glomerulonephritis Nephrol. Dial. Transplant., March 1, 2007; 22(3): 778 - 783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Myllymaki, J. Syrjanen, H. Helin, A. Pasternack, A. Kattainen, and J. Mustonen Vascular diseases and their risk factors in IgA nephropathy Nephrol. Dial. Transplant., July 1, 2006; 21(7): 1876 - 1882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Boes, D. Fliser, E. Ritz, P. Konig, K. Lhotta, J. F.E. Mann, G. A. Muller, U. Neyer, W. Riegel, P. Riegler, et al. Apolipoprotein A-IV Predicts Progression of Chronic Kidney Disease: The Mild to Moderate Kidney Disease Study J. Am. Soc. Nephrol., February 1, 2006; 17(2): 528 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Nagy, T. Kovacs, and I. Wittmann Renal protection in IgA nephropathy requires strict blood pressure control Nephrol. Dial. Transplant., August 1, 2005; 20(8): 1533 - 1539. [Full Text] [PDF]
|
|
|
|
|
|
J. Myllymaki, T. Honkanen, J. Syrjanen, H. Helin, I. Rantala, A. Pasternack, and J. Mustonen Uric acid correlates with the severity of histopathological parameters in IgA nephropathy Nephrol. Dial. Transplant., January 1, 2005; 20(1): 89 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.M. Chow, B.C. Kwan, P.K. Li, and C.C. Szeto Asymptomatic isolated microscopic haematuria: long-term follow-up QJM, November 1, 2004; 97(11): 739 - 745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Johnson, D.-H. Kang, D. Feig, S. Kivlighn, J. Kanellis, S. Watanabe, K. R. Tuttle, B. Rodriguez-Iturbe, J. Herrera-Acosta, and M. Mazzali Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease? Hypertension, June 1, 2003; 41(6): 1183 - 1190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kanellis, S. Watanabe, J. H. Li, D. H. Kang, P. Li, T. Nakagawa, A. Wamsley, D. Sheikh-Hamad, H. Y. Lan, L. Feng, et al. Uric Acid Stimulates Monocyte Chemoattractant Protein-1 Production in Vascular Smooth Muscle Cells Via Mitogen-Activated Protein Kinase and Cyclooxygenase-2 Hypertension, June 1, 2003; 41(6): 1287 - 1293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Sanchez-Lozada, E. Tapia, C. Avila-Casado, V. Soto, M. Franco, J. Santamaria, T. Nakagawa, B. Rodriguez-Iturbe, R. J. Johnson, and J. Herrera-Acosta Mild hyperuricemia induces glomerular hypertension in normal rats Am J Physiol Renal Physiol, November 1, 2002; 283(5): F1105 - F1110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Vikse, L. Bostad, K. Aasarod, D. E. Lysebo, and B. M. Iversen Prognostic factors in mesangioproliferative glomerulonephritis Nephrol. Dial. Transplant., September 1, 2002; 17(9): 1603 - 1613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nakamura, C. Ushiyama, K. Hirokawa, S. Osada, T. Inoue, N. Shimada, and H. Koide Effect of cerivastatin on proteinuria and urinary podocytes in patients with chronic glomerulonephritis Nephrol. Dial. Transplant., May 1, 2002; 17(5): 798 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Trevino-Becerra Hypertriglyceridaemia and hyperuricaemia in IgA nephropathy Nephrol. Dial. Transplant., March 1, 2001; 16(3): 639 - 639. [Full Text] [PDF]
|
|