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Nephrol Dial Transplant (1999) 14: 2210-2215
© 1999 European Renal Association-European Dialysis and Transplant Association

Case Reports

Acute interstitial nephritis with immune complex deposition and MHC class II antigen presentation along the tubular basement membrane

Masanori Tokumoto1, Kyoichi Fukuda1, Michiya Shinozaki1, Minoru Kashiwagi1, Ritsuko Katafuchi2, Tetsuhiko Yoshida1, Taihei Yanagida1, Hidetoshi Kanai1, Hideki Hirakata1, Kiyoshi Tamaki3, Seiya Okuda3 and Masatoshi Fujishima1

1 Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, 2 Kidney Center, Division of Internal Medicine, Fukuoka Red Cross Hospital Fukuoka City and 3 Third Department of Internal Medicine, Faculty of Medicine, Kurume University, Kurume City, Japan

Correspondence and offprint requests to: Masanori Tokumoto MD, The Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka City, 812-8582 Japan.

Keywords: acute renal failure; interstitial nephritis; MHC class II antigen; tubular basement membrane immune deposition



   Introduction
 
Renal tubulointerstitium has been recognized to be a common site of immune-complexes deposition leading to tissue destruction [1–3]. However, cases of interstitial nephritis in which interstitial immune complex deposition play a major role are not commonly reported [4–14]. Most reported cases have been finally diagnosed as either collagen disease or adenovirus-type 11 infection.

Here we present a case of acute interstitial nephritis with tubular immune complex depositions and MHC class II antigen expression defined on the proximal tubular cells.



   Case
 
A 66-year-old Japanese man was admitted to our hospital because of renal functional deterioration on September 19, 1995. He was well until June 1995, when he had had flu-like symptoms with low-grade fever and general malaise. He visited his primary physician in August, and trace proteinuria and increased serum creatinine were noted. Laboratory tests are listed in Table 1Go. Blood pressure was . . . [Full Text of this Article]



   Discussion
 


   Acknowledgments
 


   References
 

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A. Gupta, S. Jothy, P. Somerville, and J. S. Zaltzman
Hypocomplementaemic immune complex tubulointerstitial nephritis
NDT Plus, October 7, 2009; (2009) sfp141v1.
[Abstract] [Full Text] [PDF]