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Nephrol Dial Transplant (1999) 14: 2004-2007
© 1999 European Renal Association-European Dialysis and Transplant Association

Case Reports

De novo diabetes mellitus in kidney allografts: nodular sclerosis and diffuse glomerulosclerosis leading to graft failure

Ali K. Owda1, Abdallah H. Abdallah1, Abdul Haleem2, Fahad A. Hawas1, Dujana Mousa1, Halima Fedail1, Mohamed H. Al-Sulaiman1 and Abdullah A. Al-Khader1

1 Departments of Nephrology and 2 Pathology, Riyadh Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia

Correspondence and offprint requests to: Dr. A. K. Owda, Senior Registrar, Department of Nephrology, Riyadh Armed Forces Hospital, PO Box 7897-M605, Riyadh 11159, Saudi Arabia.

Keywords: de novo diabetic diffuse glomerulosclerosis; de novo diabetic nodular glomerulosclerosis; post-transplant diabetes mellitus; renal transplant



   Introduction
 
Post-transplant diabetes mellitus (PTDM) is a well-recognized clinical problem following renal transplantation, and occurs with incidence rates that range between 2.5 and 20% [1–4]. Despite this high incidence, there are very few reported cases of diabetic nephropathy of the diffuse type [5,6] and only a single report of the nodular sclerosis form [7].

We report (i) patient who developed PTDM 8 months after renal transplantation, with progression to the nephrotic syndrome and end-stage renal failure due to typical diabetic nodular sclerosis of Kimmelstiel—Wilson, and (ii) patients who developed PTDM 6 months and 2 years after renal transplantation respectively, who progressed to the nephrotic syndrome with impaired renal function due to diffuse diabetic glomerulosclerosis.



   Cases
 
Case 1
A 48-year-old woman who was neither diabetic nor hypertensive presented with chronic renal failure. She had no family history of diabetes mellitus and her kidney ultrasound demonstrated . . . [Full Text of this Article]

Case 2
Case 3


   Discussion
 


   References
 

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