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Nephrol Dial Transplant (1999) 14: 1997-1998
© 1999 European Renal Association-European Dialysis and Transplant Association

Case Reports

Simultaneous presentation of Goodpasture's disease and insulin-dependent diabetes mellitus

Merlin C. Thomas1, Robert J. Walker1 and Margaret Fisher2

1 Department of Nephrology, Dunedin School of Medicine, University of Otago, Dunedin and 2 Department of Immunology and Nephrology, Waikato Hospital, Hamilton, New Zealand

Correspondence and offprint requests to: Assoc. Prof. Robert Walker, Department of Medicine, Dunedin School of Medicine, University of Otago, PO Box 913, Dunedin, New Zealand.

Keywords: anti-GBM antibodies; Goodpasture's disease; insulin-dependent diabetes mellitus; simultaneous presentation



   Introduction
 
Goodpasture's disease (GD) is characterized by the presence of circulating and deposited anti-glomerular basement membrane (anti-GBM) antibodies resulting in rapidly progressive glomerulonephritis and pulmonary haemorrhage. The autoantibodies interact with the non-collagenous domain of the {alpha}3 chain of type IV collagen (Goodpasture antigen) on the basement membrane of glomeruli. A variety of autoimmune conditions have been associated with GD including insulin dependent diabetes mellitus (IDDM) [1]. We document the presentation of GD simultaneously with the onset of IDDM, suggesting the possibility of a shared pathogenesis.



   Case
 
A . . . [Full Text of this Article]



   Discussion
 


   References
 

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