Nephrology Dialysis Transplantation, Vol 14, Issue 6 1530-1535, Copyright © 1999 by Oxford University Press
G Woodrow, G Stables, B Oldroyd, J Gibson, J Turney and A Brownjohn
Background: The sustained ultrafiltration achieved by
icodextrin is more suited for the daytime dwell in automated peritoneal
dialysis (APD) than glucose solutions. Methods:
Seventeen patients receiving APD underwent assessment using three different
solutions for the daytime dwell: 2.27% glucose, 3.86% glucose and 7.5%
icodextrin. Patients were then observed on icodextrin for a 6 month period.
Results: Daytime ultrafiltration was greater for 3.86%
glucose (median 0.10, IQR 0.01 to 0.32) P<0.01 and icodextrin
(median 0.26, IQR 0.14 to 0.361) P<0.001 than 2.27% glucose (median
-0.19, IQR -0.54 to -0.081), with 3.86% glucose and icodextrin not being
significantly different. Positive ultrafiltration occurred in 3/17 patients
with 2.27% glucose, 13/17 patients with 3.86% glucose and 16/17 patients
with icodextrin &khgr;2 P<0.001). The
difference in ultrafiltration of icodextrin and 3.86% glucose correlated
with the 4 h dialysate/plasma creatinine ratio in a PET test (r=0.51,
P<0.05). Daytime Kt/V urea was greater for 3.86% glucose (median
0.27, IQR 0.20 to 0.48 per week, P<0.01) and icodextrin (median
0.31, IQR 0.27 to 0.49 per week, P<0.0001) than for 2.27% glucose
(median 0.22, IQR 0.15 to 0.38 per week), with the difference between 3.86%
glucose and icodextrin not reaching statistical significance (P=0.06).
Daytime creatinine clearance was greater for 3.86% glucose (median 10.2,
IQR 6.9 to 13.61/week/1.73 m2, P<0.02) and
icodextrin (median 12.1, IQR 9.3 to 15.71/week/1.73
m2, P<0.005) than for 2.27% glucose (median
8.8, IQR 4.9 to 11.91/week/1.73 m2). Daytime
creatinine clearance was greater for icodextrin than for 3.86% glucose
(P7lt;0.005). the effects of icodextrin were stained for the 6 month
observation period. Conclusions: Icodextrin produced
enhanced ultrafiltration and clearances compared with 2.27% glucose without
the exposure of the peritoneum to hypertonic glucose solutions.
Key words: automated peritoneal dialysis; dialysis
adequacy; icodextrin; ultrafiltration
ORIGINAL ARTICLES
Comparison of icodextrin and glucose solutions for daytime dwell in automated peritoneal dialysis
Renal Unit, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK; Centre for Bone and Body Composition Research, University of Leeds, Leeds, UK; Corresponding author
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Lin, J. Qian, X. Li, X. Yu, W. Liu, Y. Sun, N. Chen, C. Mei, and for the Icodextrin National Multi-center Cooperati Randomized Controlled Trial of Icodextrin versus Glucose Containing Peritoneal Dialysis Fluid Clin. J. Am. Soc. Nephrol., November 1, 2009; 4(11): 1799 - 1804. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M.J. Flore and J. R. Delanghe ANALYTICAL INTERFERENCES IN POINT-OF-CARE TESTING GLUCOMETERS BY ICODEXTRIN AND ITS METABOLITES: AN OVERVIEW Perit. Dial. Int., July 1, 2009; 29(4): 377 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lambie, T. Stompor, and S. Davies UNDERSTANDING THE VARIABILITY IN ULTRAFILTRATION OBTAINED WITH ICODEXTRIN Perit. Dial. Int., July 1, 2009; 29(4): 407 - 411. [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Brown, S. J. Davies, P. Rutherford, F. Meeus, M. Borras, W. Riegel, J. C. Divino Filho, E. Vonesh, and M. Van Bree Survival of Functionally Anuric Patients on Automated Peritoneal Dialysis: The European APD Outcome Study J. Am. Soc. Nephrol., November 1, 2003; 14(11): 2948 - 2957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. M. Van Hoeck, E. Rusthoven, L. Vermeylen, A. Vandesompel, B. Marescau, M. Lilien, and C. H. Schroder Nutritional effects of increasing dialysis dose by adding an icodextrin daytime dwell to Nocturnal Intermittent Peritoneal Dialysis (NIPD) in children Nephrol. Dial. Transplant., July 1, 2003; 18(7): 1383 - 1387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Schoenicke, B. Grabensee, and J. Plum Dialysis with icodextrin interferes with measurement of serum {alpha}-amylase activity Nephrol. Dial. Transplant., November 1, 2002; 17(11): 1988 - 1992. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gokal Peritoneal Dialysis in the 21st Century: An Analysis of Current Problems and Future Developments J. Am. Soc. Nephrol., January 1, 2002; 13(90001): S104 - 115. [Full Text] [PDF]
|
|
|
|
|
|
G. Woodrow, B. Oldroyd, G. Stables, J. Gibson, J. H. Turney, and A. M. Brownjohn Effects of icodextrin in automated peritoneal dialysis on blood pressure and bioelectrical impedance analysis Nephrol. Dial. Transplant., June 1, 2000; 15(6): 862 - 866. [Abstract] [Full Text] [PDF]
|
|