Nephrology Dialysis Transplantation, Vol 14, Issue 5 1244-1246, Copyright © 1999 by Oxford University Press
D Ducloux, G Motte, P Vautrin, C Bresson-Vautrin, J Rebibou and J Chalopin
Background. Insulin resistance with compensatory
hyperinsulinaemia has been reported in adult polycystic kidney disease
(APKD) patients. Diabetes mellitus is a common complication following
transplantation and previous studies have demonstrated that inadequate
insulin secretion was a prerequisite for the development of post-transplant
diabetes mellitus (PTDM). We conducted a retrospective study to determine
whether APKD is a risk factor for PTDM. Methods.
Twenty-six consecutive patients transplanted because of
end-stage renal disease due to APKD were studied. A control patient matched
for age, gender, immunosuppressive therapy and transplant year was selected
for each APKD patient. PTDM was defined by fasting glycaemia exceeding 7.8
mmol/l and the need for insulin or oral antidiabetic therapy.
Results. Age, renal function, immunosuppressive
regimen, number of acute rejection, cumulative dose of steroids and
haemodialysis duration before transplantation were similar in both groups.
PTDM occurred in 10 APKD patients and four controls (34.6%
vs 15.3%; P<0.005). Among
diabetic patients, six APKD patients and two controls required insulin
therapy (60% vs 50%; P=n.s.).
Diabetic patients were significantly older (55.8±7 years
vs 50.2±11 years;
P<0.05). Conclusion.
Although retrospective, this study suggests that APKD confers an
increased risk of PTDM. Keywords: polycystic kidney
disease; renal transplantation; post-transplant diabetes mellitus
PRELIMINARY REPORTS
Polycystic kidney disease as a risk factor for post-transplant diabetes mellitus
Department of Nephrology and Renal Transplantation, Hôpital Saint Jacques, Besançon, France; Corresponding author
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