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Nephrology Dialysis Transplantation, Vol 14, Issue 3 709-712, Copyright © 1999 by Oxford University Press

ORIGINAL ARTICLES

Effect of dialyser biocompatibility on recovery from acute renal failure after cadaver renal transplantation

J Romao, H Abensur, M de Castro, L Ianhez, V Massola and E Sabbaga
Division of Nephrology, Hospital das Clinicas , University of Sao Paulo School of Medicine, Sao Paulo, Brazil; Corresponding author address: rua Cayowaa, 560 appt. 51, 05018-020 Sao Paulo, Brazil

Background. It has been reported that patients with acute renal failure (ARF) requiring haemodialysis show an improved recovery of renal function when the dialysis treatment is performed using a biocompatible membrane rather than a bioincompatible membrane. However, most recent published human trials have not been able to confirm these findings. Method. Over a 2-year period, we prospectively studied 53 patients with ARF after cadaver renal transplantation who required haemodialysis and randomized them into two treatment groups. One group underwent dialysis with a cuprophane membrane and the other group underwent haemodialysis with a more biocompatible membrane, polysulfone. All patients received an immunosuppressive regimen which included azathiprine, prednisone and cyclosporine. Results. There was no difference by patient characteristics or immunosuppressive regimen before acute tubular necrosis (ATN) recovery. In both groups the number of haemodialysis sessions required prior to the recovery of renal function (6.57±2.79 vs 6.05±2.40), the number of oliguric days (16.25±5.14 vs 14.40±4.67) and the number of hospital days (33.38±12.85 vs 30.10±11.00), were not statistically different. There was also no difference in long-term allograft outcome. Conclusion. Our data demonstrate that the use of a more biocompatible membrane had no influence on the recovery from acute renal failure after renal transplantation. Keywords: acute renal failure; biocompatibility; dialyser membrane; haemodialysis; renal recovery; renal transplantation
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Home page
 Nephrol Dial TransplantHome page
S. M. Lang and H. Schiffl
Effect of dialyser biocompatibility on recovery from acute renal failure after cadaveric renal transplantation
Nephrol. Dial. Transplant., January 1, 2000; 15(1): 134 - 135.
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