Nephrology Dialysis Transplantation, Vol 14, Issue 3 676-682, Copyright © 1999 by Oxford University Press
M Girndt, O Heisel and H Kohler
Background. Contact between blood and dialysis
membranes activates mononuclear cells and the complement system. The extent
of activation is dependent on the dialyser material used and is considered
an index of biocompatibility. Polyamide dialysers consist of a synthetic
membrane that claims high standards of biocompatibility. Haemophan
dialysers represent membranes made of modified cellulose that are now
broadly used for treatment in Europe and are already considered to be more
biocompatible than the cuprophane membranes that were used as reference in
most previous studies. Methods. In a cross-over
treatment study short-term as well as long-term effects of a polyamide
dialyser with respect to monokine induction and complement activation were
compared to a haemophan dialyser. Results. Neither
haemophan nor polyamide dialysers induced relevant changes in plasma
monokine levels. However, in vitro challenge of
mononuclear cells with lipopolysaccharide (LPS) unmasked a significantly
stronger preactivation for the secretion of proinflammatory monokines
during haemophan than polyamide dialysis. Unlike other monokines the
production of the regulatory monokine IL-10 was mainly influenced by
individual factors and correlated with the patient's immune status rather
than the dialyser type used. Enhanced preactivation of monocytes in
haemophan compared to polyamide dialysis was paralleled by an increased
complement activation. Cellular preactivation and formation of terminal
complement complex remained constant over the 4-month treatment period.
Conclusions. Haemophan and polyamide dialysers do not
induce changes in plasma cytokine levels both during short-term and
long-term use. However, they significantly differ in complement activation
as well as preactivation of monocytes. Preactivated monocytes are prone to
secrete high amounts of proinflammatory cytokines when exposed to a second
stimulus like endotoxin. Secretion of the regulatory cytokine IL-10 is not
influenced by the dialyser type. Keywords:
biocompatibility; complement activation; haemodialysis;
interleukin-10; monokines
ORIGINAL ARTICLES
Influence of dialysis with polyamide vs haemophan haemodialysis on monokines and complement activation during a 4-month long-term study
Medical Department IV, University of Homburg/Saar, D-66421 Homburg/Saar, Germany; Corresponding author
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P.-A. Triverio, P.-O. Bridevaux, P. Roux-Lombard, L. Niksic, T. Rochat, P.-Y. Martin, P. Saudan, and J.-P. Janssens Interferon-gamma release assays versus tuberculin skin testing for detection of latent tuberculosis in chronic haemodialysis patients Nephrol. Dial. Transplant., June 1, 2009; 24(6): 1952 - 1956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mourad, S. Carney, A. Gillies, B. Jones, R. Nanra, and P. Trevillian Acute effect of haemodialysis on arterial stiffness: membrane bioincompatibility? Nephrol. Dial. Transplant., November 1, 2004; 19(11): 2797 - 2802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Klingel, M. Schaefer, A. Schwarting, F. Himmelsbach, U. Altes, I. Uhlenbusch-Korwer, and G. Hafner Comparative analysis of procoagulatory activity of haemodialysis, haemofiltration and haemodiafiltration with a polysulfone membrane (APS) and with different modes of enoxaparin anticoagulation Nephrol. Dial. Transplant., January 1, 2004; 19(1): 164 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. H. Horl Hemodialysis Membranes: Interleukins, Biocompatibility, and Middle Molecules J. Am. Soc. Nephrol., January 1, 2002; 13(90001): S62 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Sester, M. Sester, G. Heine, H. Kaul, M. Girndt, and H. Kohler Strong depletion of CD14+CD16+ monocytes during haemodialysis treatment Nephrol. Dial. Transplant., July 1, 2001; 16(7): 1402 - 1408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Girndt, U. Sester, M. Sester, H. Kaul, and H. Kohler Impaired cellular immune function in patients with end-stage renal failure Nephrol. Dial. Transplant., December 1, 1999; 14(12): 2807 - 2810. [Full Text] [PDF]
|
|