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Nephrology Dialysis Transplantation, Vol 14, Issue 2 406-408, Copyright © 1999 by Oxford University Press

PRELIMINARY REPORTS

High prevalence of hepatitis G virus (HGV) infections in dialysis staff

B Gartner, H Kaul, A Neutzling, M Sauter, N Mueller-Lantzsch and H Kohler
Department of Virology and Nephrology, Haus 47, University of Homburg/Saar, D-66421 Homburg/Saar, Germany; Corresponding author

Patients on renal replacement therapy, haemodialysis (HD), or after kidney transplantation (TX), are known to be at risk of acquiring blood-borne infections (HBV, HCV). GBV-C/Hepatitis G virus (HGV) has been described recently and is considered to cause blood-borne infections. The aim of this study was to analyse the risk for the medical staff of HD and TX patients to acquire HGV infection. Methods: Eighty-five HD patients and 86 TX recipients were compared with 49 health-care workers and 64 blood donors as controls. The HGV prevalence was determined by RT-PCR and antibodies to E2 protein. Results: A high prevalence of HGV was found in the medical staff (24%) which nearly corresponded to the prevalence of the patients (TX 36%, HD 25%) but not to the controls (9%). In contrast the prevalence of HCV was low in the medical staff (2%) and controls (0%) but high in HD (13%) and TX (13%). Age and duration of employment in the department did not significantly influence the HGV prevalence in staff. The number of viraemic subjects in staff was high, possibly indicating a more recent infection. Conclusion: An occupational risk for HGV exists in medical staff of dialysis and transplant patients. Further routes of transmission than only parenteral may play a role in this setting. Key words: haemodialysis; health care workers; hepatitis C; hepatitis G; nosocomial infection; transplant recipients
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