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Nephrol Dial Transplant (1999) 14: 2857-2859
© 1999 European Renal Association-European Dialysis and Transplant Association

Personal Opinion

Tuberculosis prophylaxis for the chronically dialysed patient—yes or no?

Asher Korzets and Uzi Gafter

Nephrology Department, Rabin Medical Center, Campus Golda, Petah Tikva, Israel

Correspondence and offprint requests to: Uzi Gafter, Nephrology Department, Rabin Medical Center, Campus Golda, Petah Tikva, Israel.

One in every three people in the world is infected with Mycobacterium tuberculosis, and observed rates of new TB infection are on the increase, especially in the third world [1–3]. In the `rich' countries, latent TB can be reactivated in a number of `high-risk' patient populations such as AIDS, silicosis, immunosuppression, malnutrition and end-stage renal failure [1–3]. Worldwide TB infection in dialysis patients ranges from 5–25% [4]. Over 40% of dialysed patients with TB have extrapulmonary manifestations of the disease, and this makes the disease difficult to diagnose, causing delay in commencing curative therapy [4]. For these reasons, TB prophylaxis in chronically dialysed patients is worthy of consideration, especially as isoniazid (INH) prophylaxis effectively reduces reactivation of latent TB for prolonged periods of time. At . . . [Full Text of this Article]

With what drug should prophylaxis be undertaken?

Which dialysed patients warrant prophylaxis?

References


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