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Nephrol Dial Transplant (1999) 14: 2855-2856
© 1999 European Renal Association-European Dialysis and Transplant Association

Personal Opinion

Is it wise to combine an ACE inhibitor and an angiotensin receptor antagonist?

Luis M. Ruilope

Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain

Correspondence and offprint requests to: Dr Luis M. Ruilope, Unidad de Hipertension, Hospital 12 de Octubre, 28041 Madrid, Spain.

Blockade of the effects of angiotensin II through the administration of angiotensin converting enzyme inhibitors (ACEi) has proven to be an effective therapy for the treatment of different forms of cardiovascular (CV) disease [1], and to reduce the velocity of progression of chronic renal failure [2,3]. A series of questions related to blockade of . . . [Full Text of this Article]

Is the nephroprotection of ACE inhibition an artifact due to blood pressure control?

Is it natural to titrate the dose of ACE inhibitors according to proteinuria?

Is it rational to combine ACE inhibitors and angiotensin receptor antagonists?

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