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Nephrol Dial Transplant (1999) 14: 2657-2663
© 1999 European Renal Association-European Dialysis and Transplant Association

Functional correlates of {alpha}2A-adrenoceptor gene polymorphism in the HANE study

Martin C. Michel, Christopher Plogmann, Thomas Philipp and Otto-Erich Brodde1

Department of Medicine, University of Essen, Essen, Germany

Correspondence and offprint requests to: Dr Martin C. Michel, Nephrology Laboratory IG1, Klinikum, Hufelandstr. 55, D-45122 Essen, Germany.

Background. The aim of this study was to test an association between alleles of the {alpha}2A-adrenoceptor gene with hereditary hypertension and with alterations of lipid and carbohydrate metabolism.

Methods. Genomic DNA was isolated from 147 hypertensive patients and digested with DraI. Genotypes at the {alpha}2A-adrenoceptor were identified by restriction fragment length polymorphism. Genotype at each locus was related to blood pressure, family history of hypertension and various clinical chemistry parameters.

Results. The {alpha}2A-adrenoceptor polymorphism was not significantly associated with blood pressure or a family history of hypertension. Patients with the d allele of the {alpha}2A-adrenoceptor had significantly lower HbA1 (5.6 vs 6.2%, P=0.0344) and HbA1c (3.4 vs 3.9%, P=0.0237) and total cholesterol (212 vs 229 mg/dl, P=0.0333) than those without. Similar trends, which failed to reach statistical significance, were seen for glucose, triglycerides and LDL cholesterol.

Conclusions. We propose that alleles at the {alpha}2A-adrenoceptor locus might contribute to interindividual differences in the regulation of human lipid and glucose metabolism.

Keywords: {alpha}2A-adrenoceptor; cholesterol; gene polymorphism; HbA1

1 Present address: Department of Pharmalogy, Martin-Luther-University, Halle, Germany.


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