Nephrol Dial Transplant (1999) 14: 2602-2606
© 1999 European Renal Association-European Dialysis and Transplant Association
Festschrift for Professor Claude Jacobs
Nephrotoxicity of contrast media
Department of Nephrology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France
Correspondence and offprint requests to: Gilbert Deray, Department of Nephrology, Group Hospitalier Pitie–Salpêtriere, 83 Boulevard de l'Hôpital, F-75651 Paris Cedex 13, France.
Intravascular iodinated contrast media administration continues to be a common cause of hospital acquired acute renal failure [1]. In the past decade our understanding of the pathogenesis of this association has led to improvement in our ability to prevent and manage this complication. In this review we have detailed the progress which has been made in this field in our department under the direction of Claude Jacobs.
Incidence of nephropathy
The reported incidence of radiocontrast-induced nephropathy (RCN) varies from 0 to 100% in retrospective studies [2,3]. This results from the lack of a single reliable definition, the method of investigation and differing patient population. Large prospective controlled studies have been reported by several authors. In non-diabetic patients with normal renal function or moderate renal insufficiency, Parfrey et al. [4] reported an incidence of RCN at 2.1–2.4% but no significant difference was found between these patients
Clinical presentation
Risk factors
Mechanisms
Renal tolerance of LOCM and non-ionic dimers
References
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