Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (7)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Palm, C.
Right arrow Articles by Gross, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Palm, C.
Right arrow Articles by Gross, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (1999) 14: 2559-2562
© 1999 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

V2-vasopressin receptor antagonists—mechanism of effect and clinical implications in hyponatraemia

Catrin Palm and Peter Gross

Division of Nephrology, Department of Medicine, Universitätsklinikum C. G. Carus, Dresden, FRG

Correspondence and offprint requests to: Dr Catrin Palm, Division of Nephrology, Department of Medicine, Universitätsklinikum C. G. Carus, Fetscherstr. 74, D-01307 Dresden, FRG.

Keywords: cardiac failure; liver cirrhosis; syndrome of inappropriate antidiuretic hormone secretion; treatment of hyponatraemia; vasopressin; vasopressin receptor antagonists

Introduction

Hyponatraemia (serum sodium <135 mmol/l) is the most frequent electrolyte disturbance in clinical practice. Its clinical relevance is related to both the symptoms it causes and the state of cardiovascular dysfunction it indicates. Hyponatraemic patients may suffer from lethargy, difficulty of concentration, disorientation, muscular cramps, grand mal seizures, and even coma. It is important to know that these symptoms are more related to the rate of decrease of serum sodium concentration than to the absolute level of a hyponatraemia reached. This surprising observation is related to the phenomenon of osmotic unloading of cells, which causes adaptation of cell volume to any given degree of hyponatraemia within 2–4 days. Osmotic reloading will have to occur during correction of hyponatraemia. Since this will take a similar amount of time to be completed, the rate of correction of hyponatraemia should not be in excess of 0.5 mmol/l/h. If chronic hyponatraemia is corrected too . . . [Full Text of this Article]

Pathophysiological significance of hyponatraemia

Significance of hydro-osmotic V2-vasopressin receptors

Pharmacology of vasopressin V2 receptor antagonists

Studies of vasopressin V2 antagonists in cardiac failure

Studies of vasopressin V2 antagonists in liver cirrhosis

Studies of V2 vasopressin antagonists in SIADH

Conclusions

References


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
W. T. Abraham, A. A. Shamshirsaz, K. McFann, R. M. Oren, and R. W. Schrier
Aquaretic Effect of Lixivaptan, an Oral, Non-Peptide, Selective V2 Receptor Vasopressin Antagonist, in New York Heart Association Functional Class II and III Chronic Heart Failure Patients
J. Am. Coll. Cardiol., April 18, 2006; 47(8): 1615 - 1621.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
T. J. Vachharajani, F. Zaman, and K. D. Abreo
Hyponatremia in Critically Ill Patients
J Intensive Care Med, January 1, 2003; 18(1): 3 - 8.
[Abstract] [PDF]