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Nephrol Dial Transplant (1999) 14: 2495-2498
© 1999 European Renal Association-European Dialysis and Transplant Association

Case Reports

Post-renal transplant azathioprine-induced pancreatitis

Vikas Siwach, Virinder Bansal, Avneesh Kumar, Umamehashwara Rao Ch, Ajay Sharma and M. Minz

Transplant Surgery Unit, Department of Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence and offprint requests to: Dr M. Minz, #121-A, Sector 24-A, Chandigarh—160 023, India.

Keywords: azathioprine; pancreatitis; renal transplantation



   Introduction
 
Acute pancreatitis is a rare but often lethal complication in post-transplant patients. Azathioprine is one of the incriminated agents out of the multiple possible aetiological factors.

We present a case who developed acute necrotizing pancreatitis while on immunosuppression, which included azathioprine, for more than a year in the post-transplant period, and review the literature regarding possible aetiopathogenesis and management of post-transplant drug-induced pancreatitis.



   Case
 
In December 1996, a 48-year-old man with chronic renal failure due to glomerulonephritis received a renal transplant from a live genetically unrelated donor. Immunosuppressive regimen comprised cyclosporin, azathioprine, and corticosteroids. The post-operative course was unremarkable, with satisfactory renal function. There was no episode of rejection or infection during this period.

In January 1998 the patient was admitted with acute epigastric pain, non-colicky, characteristically radiating to the back and decreasing on stooping forward. Serum amylase was raised (320 Somogyi units/dl). Dynamic CAT scan of the abdomen showed features . . . [Full Text of this Article]



   Discussion
 


   References
 

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