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Nephrol Dial Transplant (1999) 14: 2489-2491
© 1999 European Renal Association-European Dialysis and Transplant Association

Case Reports

Tacrolimus (FK506)-induced severe and late encephalopathy in a renal transplant recipient

Philippe Grimbert1, Christine Azema1, Myriam Pastural1, Djamel Dhamane1, Philippe Remy1, Laurent Salomon2, Fredérique Schortgen3, Christophe Baron1 and Philippe Lang1

1 Department of Nephrology, 2 Department of Urology and 3 Intensive Care Unit, Hôpital Henri Mondor, Creteil, France

Correspondence and offprint requests to: Dr Philippe Lang, Service de Nephrologie, Hôpital Henri Mondor, 51 avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France.

Keywords: neurological complications; renal transplantation; tacrolimus



   Introduction
 
Tacrolimus (FK506) is an effective immunosuppressive agent for the prevention of organ transplant rejection. The neurological complications of tacrolimus therapy that have been reported are usually mild, i.e. tremors, paresthesia and mild organic brain syndrome, but occasionally severe, i.e. aphasia, ataxia, severe organic brain syndrome, confusion, seizures and coma [1]. Severe neurological complications have been observed mostly after liver and lung transplantation. They are the result of high plasma FK506 levels or of a predisposing condition [2].

We observed an unusual case of severe encephalopathy which occurred late after renal transplantation in the absence of overdose, metabolic abnormalities or history of neurological disease.



   Case
 
A 64-year-old woman underwent renal transplantation in May 1996 for chronic glomerulonephritis. Except for renal disease, she had . . . [Full Text of this Article]



   Discussion
 


   References
 

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