Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Müller, A.
Right arrow Articles by van der Woude, F. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Müller, A.
Right arrow Articles by van der Woude, F. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (1999) 14: 2482-2483
© 1999 European Renal Association-European Dialysis and Transplant Association

Case Reports

Serious bleeding in a haemodialysis patient treated with recombinant hirudin

Alexander Müller1, Günter Huhle2, Rainer Nowack1, Rainer Birck1, Dieter L. Heene2 and Fokko J. van der Woude1

1 Fifth Medical Clinic and 2 First Medical Clinic, University Hospital Mannheim, Medical Faculty of the University of Heidelberg, Germany

Correspondence and offprint requests to: Dr Alexander Müller, V. Medizinische Klinik, Universitätsklinik Mannheim GmbH, Theodor-Kutzer-Ufer 1–3, D-68135 Mannheim, Germany.

Keywords: anticoagulation; ecavin clotting time; haemodialysis; heparin-induced thrombocytopenia (HIT); hiradin; thrombosis



   Introduction
 
Heparin is at present the most widely used anticoagulant for haemodialysis to prevent clotting in the extracorporal circuit. Heparin-induced thrombocytopenia (HIT) type II is a serious complication rendering the further administration of unfractioned heparin as well as low-molecular-weight heparin impossible. Even available heparinoids such as danaparoid exhibit a significant cross-reactivity with HIT antibodies in 5–10% of patients and is sometimes not suitable for anticoagulation in cases of heparin intolerance. Hirudin is a direct thrombin inhibitor which forms non-covalent complexes with thrombin. . . . [Full Text of this Article]



   Case
 


   Discussion
 


   References
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
M. J. Flanigan
Melagatran anticoagulation during haemodialysis--'Primum non nocere'
Nephrol. Dial. Transplant., September 1, 2005; 20(9): 1789 - 1790.
[Full Text] [PDF]