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Nephrol Dial Transplant (1999) 14: 2461-2463
© 1999 European Renal Association-European Dialysis and Transplant Association


Case Reports

Chronic graft-versus-host disease complicated by membranous glomerulonephritis

Gökhan Nergizoglu1, Kenan Keven1, Kenan Ates1, Celaletttin Üstün2, Özden Tulunay3, Meral Beksaç2, Oktay Karatan1 and A. Ergün Ertug1

1 Departments of Nephrology, 2 Haematology and 3 Pathology, Ankara University School of Medicine, Ibn-i Sina Hospital, Ankara, Turkey

Correspondence and offprint requests to: Gökhan Nergizoglu, Sehit Cemalettin cad. 117/7, Aydinlikevler, 06130, Ankara, Turkey.

Keywords: graft-versus-host disease; nephrotic syndrome



   Introduction
 
Graft-versus-host disease (GVHD) is a major complication of patients who undergo allogeneic haematopoietic stem cell transplantation (alloHSCT). It occurs in 50% of patients with alloHSCT and results from recognition of recipient tissues by the engrafted donor T cells [1]. Whilst clinical manifestations appear within the first few weeks after transplantation in the acute form, the chronic form occurs a few months to a year following transplantation. Many of the features seen in chronic form GVHD (cGVHD) are similar to various immune complex disorders such as collagen vascular diseases. Although murine GVHD has been studied as a model of lupus nephritis [2], in humans glomerulonephritis is rare in bone marrow transplant . . . [Full Text of this Article]



   Case
 


   Discussion
 


   References
 

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