Nephrology Dialysis Transplantation, Vol 13, Issue 12 3074-3078, Copyright © 1998 by Oxford University Press
O Lenz, F Zheng, J Vilar, S Doublier, E Lupia, S Schwedler, L Striker and G Striker
Background. Glomerulosclerosis, the common terminal
event in chronic glomerular diseases such as diabetic nephropathy or IgA
nephropathy, leads to end-stage renal disease. The considerable variation
in both the risk of developing glomerulosclerosis and the rate of
progression in individual patients suggest a role for genetic factors which
have not been identified so far. In this study we sought to examine the
mode of inheritance of glomerulosclerosis in mice. Methods.
F1 animals of a mating between glomerulosclerosis-prone
ROP-Os+ male and non-sclerotic C3H female mice were
backcrossed to the ROP strain. We took advantage of the radiation-induced
mutation oligosyndactylism (Os) to identify
glomerulosclerosis at the age of 3 months. Kidneys were perfused
in situ with PBS/Formalin 10%. The extent of
glomerulosclerotic lesions was evaluated on PAS stained paraffin sections
using computer-aided morphometry. Results. F1 mice did
not show any glomerulosclerosis. In the backcross offspring, we found a
wide distribution of glomerular lesions between individual animals, ranging
from normal to very severe. We calculated that at least 8-10 loci determine
the severity of glomerulosclerosis in mice. Conclusions.
Our data show that glomerulosclerosis is inherited in a
recessive fashion involving at least 8-10 loci. Keywords:
genetics; glomerulosclerosis; mice; oligosyndactyly
ORIGINAL ARTICLES
The inheritance of glomerulosclerosis in mice is controlled by multiple quantitative trait loci
Renal Cell Biology Section, Metabolic Diseases Branch, NIDDK, NIH, Bethesda, MD, USA; INSERM U319, Paris, France; Ivax Research Institute, 4400 Biscayne Boulevard, Miami, FL 33137, USA; Current address: Renal Cell Biology Laboratory, Division of Nephrology, Department of Medicine, University of Miami School of Medicine, PO Box 016960 (R-126), Miami, FL 33101, USA; Corresponding author
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