Nephrology Dialysis Transplantation, Vol 13, Issue 1 113-117, Copyright © 1998 by Oxford University Press
J Navarro, R Marcen, J Teruel, R del Rio, C Gamez, C Mora and J Ortuno
Background: We analysed amino-acid losses during
haemodialysis, their influence on plasma amino-acid concentration, and
their possible effects on nutritional state. Methods:
Five patients were dialysed with three membranes: cuprophan (CUP),
polysulphone (PS), and polyacrylonitrile AN69 (PAN). We compared
anthropometric and biochemical parameters after 6 months in patients
dialysed with CUP respect to patients with PAN.
Results: Total losses of amino acids were higher with
PAN than with PS and CUP (6.1±2.3 vs
3.8±1.3, P <0.05, and 3.7±1.3 g/session, P
<0.01 respectively). Losses of essential amino acids (EAA) and
non-essential amino acids (NEAA) were also higher with PAN respect to PS
and CUP (1.8±0.8 vs 1±0.3 and
0.8±0.3, and 4.3±1.6 vs
2.8±1 and 2.9±1.1 g/session, P <0.05). The
percentage reduction for plasma EAA and NEAA were lower with CUP respect to
PS and PAN (11±5% and 20±14% vs
25±10% and 33±11%, and 30±11% and
25±17% respectively, P <0.05). There was no difference in
the nutritional state between patients with CUP and PAN. However, plasma
valine in patients with PAN was lower than in those with CUP
(1.88±0.12 vs 2.13±0.32 mg/dl)
and almost reached statistical significance.
Conclusions: New synthetic membranes are advantageous
with respect to conventional ones, but a disadvantage is the higher
amino-acid losses, especially with polyacrylonitrile. Long-term studies are
necessary to evaluate the impact of amino-acid losses on nutritional state
in patients dialysed with these membranes. Key words:
amino acid losses; haemodialysis; dialysis membrane; biocompatibility;
nutritional state
ORIGINAL ARTICLES
Effect of different membranes on amino-acid losses during haemodialysis
Department of Nephrology, Hospital Ntra. Sra. de Candelaria, 28010 S/C de Tenerife, Spain; Department of Nephrology and Research Unit, Hospital Ramon y Cajal, Madrid, Spain; Corresponding author
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