Nephrology Dialysis Transplantation, Vol 12, Issue 12 2673-2678, Copyright © 1997 by Oxford University Press
K Kostner, R Oberbauer, U Hoffmann, T Stefenelli, G Maurer and B Watschinger
Background: Increased plasma Lipoprotein (a) (Lp(a))
levels are strongly associated with premature cardiovascular disease and
stroke. The kidney is purported to play an important role in apo(a)
catabolism. Therefore we investigated plasma Lp(a) levels in relation to
kidney function and urinary apo(a) excretion. Methods:
One hundred and sixteen kidney transplant patients with normal or impaired
renal function and 109 age- and sex-matched healthy controls were
investigated. Plasma Lp(a) and urinary apo(a) levels were determined by
routine laboratory methods. Results: Transplant
recipients were found to have significantly elevated total cholesterol and
LDL-C values, but equal HDL-C values compared to controls. Plasma Lp(a)
values were higher and urinary apo(a) excretion was lower in transplant
recipients compared to controls, independent of renal function. When the
patient group was subdivided into 'normal' and 'impaired creatinine
clearance', only the latter group secreted less apo(a) than normal
controls. Conclusion: These data suggest that urinary
apo(a) excretion is reduced in transplant recipients with impaired
excretory graft function, which may contribute to the elevation of plasma
Lp(a) levels in these patients. Key words: Lp(a)
metabolism; proteinuria; renal function
ORIGINAL ARTICLES
Urinary excretion of apo(a) in patients after kidney transplantation
Second Department of Medicine, Division of Cardiology, Third Department of Medicine, Division of Nephrology, Waehringerguertel 18-20, A-1090 Vienna, Austria; Corresponding author
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