In This Issue
A rather provocative editorial comment on the recently published studies of the "wearable kidney" questions the true originality of the application of this device to manage fluid overload.See article by Shaldon and Lysaght, pages 2716–2717
The role of many endogenous cardiotonic steroids in sodium homeostasis and uraemic cardiomyopathy is elegantly summarized in a comprehensive editorial comment by Schoner and Scheiner-Bobis.
See article by Schoner and Scheiner-Bobis, pages 2723–2729
What you always wanted to know about the strengths and weaknesses of meta-analysis: a French cuisine approach.
See article by Van Biesen et al., pages 2729–2732
Pioglitazone attenuates experimental diabetic nephropathy not only by improving glucose metabolism and insulin resistance but also by anti-inflammatory mechanisms.
See article by Ko et al., pages 2750–2760
Calcimimetic agents efficiently reduce plasma parathyroid hormone (PTH) and calcium phosphate product in patients with uraemic hyperparathyroidism, but in experimental uraemia cincacalcet has no impact on growth plate chondrocyte function, but improves food efficiency and body weight gain.
See article by Nakagawa et al., pages 2761–2767
Little is known about predictors of change in GFR in the normal population. This population-based study found that the higher albumin/creatinine ratio was associated with a decline in eGFR in men only. Thus, some risk factors for change in GFR seem to be gender specific, but both high systolic blood pressure and high levels of fibrinogen contribute to a more rapid decline in GFR for both men and women.
See article by Kronborg et al., pages 2818–2826
Serum levels of TGF-β1 are highly elevated and strongly associated with urinary albumin excretion in patients with essential hypertension. Treatment with benazepril or valsartan attenuates serum TGF-β1 levels and microalbuminuria. Serum TGF-β1 could thus be a potential surrogate marker in monitoring the development and progression of kidney damage in essential hypertension.
See article by Zhu et al., pages 2841–2846
Cardiopulmonary bypass has been identified as a major acute kidney injury (AKI) risk factor after coronary artery bypass surgery. This study found that off-pump CABG which avoids cardio-pulmonary bypass was associated with a significantly lower rate of and less severe AKI compared to the on-pump technique.
See article by Massoudy et al., pages 2853–2860
It has been suggested that status as a ‘non-dipper’, determined from 24-h blood pressure (BP) recordings, is associated with increased risk of end-organ damage. A post hoc analysis of a prospective study in progressive CKD, stages 3–5 could not find a correlation between dipper status and GFR, decline in renal function, degree of albuminuria or BP level.
See article by Elung-Jensen et al., pages 2873–2878
A careful histopathological study on parathyroid glands obtained in patients on haemodialysis found convincing evidence for a significantly higher number of vessels expressing CD105, b-FGF and VEGF, suggesting enhanced angiogenesis.
See article by Martins et al., pages 2889–2894
From a Japanese study it could be recommended that cardiac troponin T should be measured as part of a strategy for detecting asymptomatic coronary artery stenosis, especially multi-vessel disease, in asymptomatic patients at the start of RRT.
See article by Hayashi et al., pages 2936–2942
Bone morphogenic protein-7 (BMP-7) is a key factor in epithelial-to-mesenchymal transition. This study found that the peritoneal BMP-7 level correlates with peritoneal transport characteristics, and a high dialysate effluent level is associated with a gradual increase in peritoneal transport parameters with time.
See article by Szeto et al., pages 2989–2994
Despite the claim that cystatin C is more sensitive to detect mild GFR, in this Canadian study it did not confer any advantage with respect to preoperative assessment of kidney function or for monitoring following live kidney donation as compared to more traditional measures.
See article by Gourishankar et al., pages 3004–3009
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