In this issue
Both the RIFLE and the AKIN classification systems for definition of acute kidney injury (AKI) have recently been introduced. One article and an accompanying editorial comment discuss these systems and come to the conclusion that in fact both are more or less the same.See article by Bagshaw et al., pages 1569–1574 and editorial comment by Kellum, pages 1471–1472
Several recent studies have shown that a brief ischaemia applied during the onset of reperfusion (postconditioning) is protective against ischaemic damage in different organs. An original article describes that postconditioning reduced renal functional injury and also reduces mitochondria respiratory chain impairment, mitochondria peroxide production and protein damage.
See article by Serviddio et al., pages 1504–1512
Kidney involvement in Fabry disease is more prevalent and heterogeneous than previously reported. Proteinuria is an early complication, but may not be overt in patients with advanced kidney disease. A significant proportion of females suffer from moderate to severe kidney involvement in Fabry disease.
See article by Ortiz et al., pages 1600–1607
A meta-analysis showed that low birth weight in children with minimal change nephrotic syndrome is associated with more steroid resistance, a higher number of relapses and a higher chance of developing several complications during the follow-up period, including hypertension.
See article by Teeninga et al., pages 1615–1620
Prevention of haemodialysis catheter-related bacteraemia with antimicrobial lock solutions seems to be effective according to a meta-analysis of prospective randomized trials.
See article by Labriola et al., pages 1666–1672
Time below K/DOQI haemoglobin target in dialysis patients is related to higher risk of hospitalization and death.
See article by Ishani et al., pages 1682–1689
The link between anaemia and congestive heart failure in the first year post-transplantation was explored in 132 incident transplant patients. It is suggested that both are associated and that reducing post-transplant anaemia may in turn reduce the incidence of congestive heart failure.
See article by Borrows et al., pages 1728–1734
Relevant hyperkalaemia associated with ACEI/ARB therapy is negligible in renal transplant recipients during long-term follow-up. The hyperkalaemic effect of ACEI/ARB is balanced by the use of diuretics.
See article by Mitterbauer et al., pages 1742–1746
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