In this issue
The ethics related to living organ donation, the associated problem of organ trafficking and financial compensation of the living donor are discussed in a highly readable editorial comment.See editorial comment by Danovitch, pages 1089–1092
Is the growing epidemic of CKD more perception than reality? Fact or fiction? These articles present a high-level debate between two groups of distinguished authors, with a European viewpoint on this problem.
See articles by Glassock and Winearls, pages 1117–1121; Coresh et al., pages 1122–1125; and the editorial comment by de Jong and Gansevoort, pages 1092–1095
Periodic paralyses: a perplexing problem in nephrology is very well explained in a comprehensive editorial accompanying a fascinating case report in this issue.
See editorial comment by Lengelé et al., pages 1098–1101; and the case report by Grgic et al., pages 1449–1451
The cellular location and kinetics of renal hypoxia, as well as potential hypoxia adaptation in acute kidney injury (AKI) induced by rhabdomyolysis, were investigated in a rat model. Myoglobin seems to contribute to hypoxia generation and pharmacologic enhancement of the involved hypoxia-inducible factors (HIFs) may have the potential to improve rhabdomyolysis-induced AKI.
See article by Rosenberger et al., pages 1135–1143
Experimentally-induced hyperuricaemia in rats causes hypertension and renal alterations which can be prevented by lowering uric acid with febuxostat, a more effective uric acid lowering agent than allopurinol.
See article by Sánchez-Lozada et al., pages 1179–1185
A detailed clinical and genetic study of the second family in the literature with familial pure proximal renal tubular acidosis revealed that the mode of inheritance is compatible with an autosomal dominant disease.
See article by Katzir et al., pages 1211-1215
The clinical outcomes of a comparison between gadolinium and iodine contrast for percutaneous intervention in renal artery stenosis indicate that gadolinium is effective and associated with lower incidence of contrast nephropathy and early progression to ESRD in patients with pre-existing CKD.
See article by Kane et al. pages 1233–1240
CKD is prevalent and often unrecognized in the residential care home population. It was found that, based on the MDRD formula, 10% of this population was in stage 4.
See article by Carter et al., pages 1257–1264
A Finnish study found that, besides the known risk factors such as hypertension, proteinuria and renal insufficiency, inflammatory markers including hs-CRP, s-albumin, and white blood cell count are associated with the progression of IgA glomerulonephritis.
See article by Kaartinen et al., pages 1285–1290
The incidence and severity of pancreatitis seem to be higher in peritoneal dialysis than in haemodialysis patients.
See article by Lankisch et al., pages 1401–1405
The problem of complex cardiac arrhythmias was explored in haemodialysis patients; a greater arrhythmogenic activity was found with the use of a constant and relatively low K concentration as compared with decreasing K profiling in arrhythmia-sensitive patients.
See article by Santoro et al., pages 1415–1421
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