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NDT Advance Access originally published online on May 29, 2008
Nephrology Dialysis Transplantation 2008 23(10):3372; doi:10.1093/ndt/gfn263
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© The Author [2008].
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org


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Nephrol Dial Transplant 2008; doi:10.1093/ndt/gfn251

E-mail: schaefe{at}uni-muenster.de

Sir,

We appreciate the interest of O. Vaage-Nilsen who claims that in our article [1] we had not distinguished between high-molecular-weight (Dexferrum®) and low-molecular-weight (INFed®) dextran. This of course is not the case. We were quoting an article by Chertow et al. [2], of which Mr Vaage-Nilsen is an author as well, clearly showing that the reported numbers of life-threatening events over a 3-year period were 6/10.000.000 with iron sucrose versus 33/10.000.000 for the INFed iron dextran. Rare events indeed, but still a striking difference nonetheless. For these reasons the European Best Practice Guidelines—published in this learned journal do discourage the use of all iron dextran species, irrespective of their molecular weight [3].

Conflict of interest statement. None declared.

Liliana Schaefer1 and Roland M. Schaefer2

1 Institute of Pharmacology and Toxicology, University of Frankfurt Frankfurt 2 Department of Medicine University of Muenster Muenster Germany

References

  1. Schaefer L, Schaefer RM. A primer on iron therapy. Nephrol Dial Transplant (2007) 2:2429–2431.
  2. Chertow GM, Mason PD, Vaage-Nilsen O, et al. Update on adverse drug events associated with parenteral iron. Nephrol Dial Transplant (2006) 21:378–382.[Abstract/Free Full Text]
  3. Locatelli F, et al. Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure. Nephrol Dial Transplant (2004) 19(Suppl_2):ii1–47.[Free Full Text]

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This Article
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