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Nephrology Dialysis Transplantation 2007 22(Supplement 7):vii194-vii244; doi:10.1093/ndt/gfm408
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Appendix



   Appendix A—The Renal Registry Statement of Purpose
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
  1. Executive summary
  2. Introduction
  3. Statement of intent
  4. Relationships of the Renal Registry
  5. The role of the Renal Registry for patients
  6. The role of the Renal Registry for nephrologists
  7. The role of the Renal Registry for Trust managers
  8. The role of the Renal Registry for commissioning agencies
  9. The role of the Renal Registry national quality assurance schemes
  10. References and websites



   A1 Executive summary
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(1.1) The Renal Registry was established by the Renal Association to act as a resource in the development of patient care in renal disease.
(1.2) The Registry acts as a source of comparative data for audit/benchmarking, planning, policy and research. The collection and analysis of sequential biochemical and haematological data is a unique feature of the Registry.
(1.3) Agreements have been made with participating renal centres, which ensure a formal relationship with the Registry and safeguard confidentiality.
(1.4) The essence of the agreement is the acceptance of the Renal Registry Data Set Specification (RRDSS) as the basis of data transfer and retention.
(1.5) Data is collected quarterly to maintain unit-level quality assurance, with the results being published in an annual report.
(1.6) Activity is funded from commissioning agencies by a capitation fee on renal patients.
(1.7) The Registry is responsible, with the express agreement of participants, for providing data to Trusts, Primary Care Trusts (PCTs), commissioning authorities and the European Renal Association–European Dialysis and Transplant Association (ERA–EDTA) Registry.
(1.8) The development of the Registry is open to influence from all interested parties, including clinicians, Trusts, commissioning authorities and patient groups.
(1.9) The Registry is non-profit making and has a registered charitable status through the Renal Association.



   A2 Introduction
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(2.1) Registry-based national specialty comparative audit is one of the cornerstones of NHS development. The Renal National Service Framework (NSF), published in two sections in 2004 and 2005, recommended the participation of all renal units in comparative audit through the Renal Registry, with co-temporaneous documents defining the necessary information strategies [1–4].
(2.2) The shape of future national audit will be set not only by conventional medical criteria, but also by NSF recommendations, prompted through the Healthcare Commission. The necessary detail is currently the subject of a formal scoping project, in which the Registry is represented. The final relationship of the Registry to the Healthcare Commission has yet to be defined.
(2.3) The Chief Executives of Trusts are responsible for clinical governance, and audit will be an essential part of that agenda [5].
(2.4) Demographic information on patients receiving renal replacement therapy (RRT) throughout Europe was collected from 1965 in the Registry of the ERA–EDTA. This voluntary exercise was conducted on paper and by post, demanded considerable effort and time from participating units and eventually proved impossible to sustain. Latterly, the incompleteness of UK data returns to ERA–EDTA made it impossible to build a picture of the activity of RRT in the UK for planning and policy purposes. Subsequently, five ad hoc national data collections from England & Wales were solicited from renal centres in 1992, 1996, 1999, 2002 and 2004 to fill this gap. The Registry is well placed to put such surveys on a permanent and regular footing, and extend their remit, to chronic kidney disease (CKD), for example.
(2.5) Together with the need to know the demographic and structural elements, the NHS has developed a need to underpin clinical activity more rigorously through the scientific evidence base (for example, the Cochrane Initiative) and by quality assurance activity through audit. These initiatives require comprehensive information about the structures, processes and outcomes of RRT, which go well beyond the detail previously compiled by the ERA–EDTA.
(2.6) The Registry is recognized as one of the very few high-quality clinical databases available for general use [6]. The collection of data by download of electronic records from routine clinical databases is uncommon, has been highly successful, and is being imitated worldwide.
(2.7) The Renal Association has made a start in the area of audit by publishing guidelines in ‘Renal Standards’ documents. It was apparent during the development of the Standards that many of the desirable criteria of clinical performance were uncertain or unknown, and that only the accumulated data of practising renal units could provide the evidence for advice on best practice and what might be achievable. A common data registration provides the simplest device for such an exercise.
(2.8) The continuing emphasis on evidence-based practice is being supported by changes in research funding (Culyer Report and recent national statements), which lean towards collaborative projects and include both basic science and ‘health services research’ components. It is apparent that an RRT database is invaluable to a wide range of research studies.
(2.9) It can be seen that the need for a Registry of RRT has developed for a variety of reasons: international comparisons, national planning, local Trust, Primary Care Trust (PCT) and health authority management, standard setting, audit and research. The opportunity for data gathering arises partly from improvements in information technology. Although it was possible to see the need for a national renal database 20 years ago, the circumstances have become ideal for the maintenance of a data repository, supported by the clinical users and resourced for national benchmarking as a routine part of RRT management.
(2.10) The provisional expectations of earlier Annual Reports can now be replaced by confident assertions, built on the experience of 7 years of publication, about the role and potential of the Registry. The integration of the various elements of Renal Association strategy is being pursued through the recently established Clinical Affairs Board (CAB).



   A3 Statement of intent
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
The Renal Registry provides a focus for the collection and analysis of standardized data relating to the incidence, clinical management and outcome of renal disease. Data will be accepted quarterly according to the RRDSS by automatic downloading from renal centre databases. There will be a core data set, with optional elements of special interest that may be entered by agreement for defined periods. A report will be published annually to allow a comparative audit of facilities, patient demographics, quality of care and outcome measures. Participation is mandated through the recommendation in the Renal NSF. There will be an early concentration on RRT, including transplantation, with an extension to other nephrological activity at a later date. The Registry will provide an independent source of data and analysis on national activity in renal disease.



   A4 Relationships of the Renal Registry
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(4.1) The Registry is a registered charity through the Renal Association (No. 2229663). It was established by a committee of the Renal Association, with additional representation from the British Transplantation Society, the British Association for Paediatric Nephrology, the Scottish Renal Registry, Wales and Northern Ireland. There is cross-representation with both the Renal Association Standards and Clinical Trials Committees and the Clinical Affairs Board. The Registry has a Chairman and Honorary Secretary nominated by the Renal Association. The Registry has an observer from the Department of Health, a participant from the National Kidney Federation (NKF) (patients’ association) and a member representing the Health Care Commissioners.
(4.2) A number of sub-committees have been instituted as the database and renal unit participation developed, particularly for data analysis and interpretation for the Annual Report. Further specialized panels may be developed for publications and the dissemination of Registry analyses.
(4.3) The Scottish Renal Registry sends data to the Renal Registry for joint reporting and comparison.
(4.4) The return of English, Welsh and Northern Ireland data to the ERA Registry will be through the Renal Registry. The Scottish Renal Registry already sends data directly to the ERA Registry.
(4.5) A paediatric database has been developed in collaboration with the Renal Registry, and the two databases are compatible. These two databases are in the process of being integrated, which will allow long-term studies of renal cohorts over a wide range of age.
(4.6) Close collaboration has been achieved with UK Transplant to the benefit of both organizations. Data aggregation and integration has led to joint presentations and publications. The description of the entire patient journey in RRT by this means is a source of continuing insight and usefulness.
(4.7) The basis of participation for renal units nationally is an agreement to accept the RRDSS for the transmission and retention of data. This consists of a core data set of some 200 items and further optional elements, which will be returned on a special understanding with the unit for a defined period of reporting. The data set is a considerable part of a National Renal Dataset (England) being developed currently by a project team, which includes Registry representation.
(4.8) The Registry is part of the team undertaking an investigation into the necessary scope of national audit for the Healthcare Commission, in the light of the NSF.
(4.9) The retention of patient identifiable information, necessary in particular for the adequate tracing of patients, has been approved by the Patient Information Advisory Group (PIAG), under Section 60 of the Health and Social Care Act. This is pending the introduction of mechanisms that will preserve patient anonymity through encryption of a unique patient identifier.
(4.10) It is anticipated that the Registry will receive data from the secondary users service (SUS) of the national IT programme, Connecting for Health, when it is fully instituted. The detail of data routing from renal unit clinical systems to the national database has yet to be established.



   A5 The role of the Renal Registry for patients
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(5.1) The goal of the Registry is to improve care for patients with renal disease. The appropriate use of Registry information should improve equity of access to care, adequacy of facilities, availability of important but high-cost therapies such as erythrocyte-stimulating agents and the efficient use of resources. The continuing comparative audit of the quality of care should facilitate the improvement of care and outcomes of care. It is intended to identify and publish examples of good practice. In such ways, patients will be the ultimate beneficiaries of the exercise.
(5.2) A leaflet has been provided, in collaboration with the NKF, by which patients may opt out of the collection of identifiable data by the Registry, if they wish.
(5.3) Information from the Registry will complement the individual records available on ‘Renal Patient View’ where it is accessible.



   A6 The role of the Renal Registry for nephrologists
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(6.1) The clinical community have become increasingly aware of the need to define and understand their activities, particularly in relation to national standards and in comparison with other renal units.
(6.2) The Registry is run by a committee of the Renal Association and therefore by colleagues with similar concerns and experience.
(6.3) The Renal Standards documents are designed to give a basis for unit structure and performance, as well as patient-based elements such as case mix and outcomes. It is anticipated that Standards will become increasingly based on research evidence and the Cochrane Collaboration has recently resourced reviews of renal topics, which will support this conversion.
(6.4) The Registry data are available to allow the comparative review of many elements of renal unit practice. Centre data are presented to allow a contrast of individual unit activity and results against national aggregated data. Sophisticated analyses of patient survival, for example, are a unique resource to exclude any anomalies of performance and standardize for unit caseload, etc.
(6.5) Reports of demographic and treatment variables are available to the participating centres for distribution to Trusts, PCTs, Strategic Health Authorities and Commissioners, as well as Renal networks, as required and agreed with the unit. Reports should facilitate discussion between clinicians, Trust officers and commissioners.
(6.6) Customized data reports can be made available by agreement with the Registry Committee. A donation to cover any costs incurred may be requested.
(6.7) The Registry is developing the publication of focused and extended synopses of chapters from the annual Report. These ‘dips’ will facilitate the appreciation and application of comparative data and will allow wider distribution.
(6.8) The Registry Committee welcome suggestions for topics of national audit or research that colleagues feel are of sufficiently widespread interest for the Registry to undertake.
(6.9) The database has been designed to provide research facilities for future participation in national and international trials. Members of the Renal Association and other interested parties are welcome to apply to the Registry committee to conduct local or national audit and research using the database. All such projects will need the agreement of the Registry Committee, and any costs involved will need to be met by the applicants.
(6.10) These facilities will be sustainable only through cooperation between nephrologists and the Registry. There is a need for high quality and comprehensive data entry at source.
(6.11) The sustaining of data collection, organization and transmission from peripheral sites is not centrally resourced. The lack of clear status for many informatics staff at unit level, the imminent inroads of the national IT programme Connecting for Health and the potential disruptions of Agenda for Change will be balanced by the development of formal informatics organizations (The UK Council for Health Informatics Professions (UK CHIP [7]), the NHS Faculty of Health Informatics [8] and the Association of ICT Professionals in Health and Social Care (ASSIST [9]).
(6.12) Units will need to develop an ‘annual informatics plan’, to review the maintenance and improvement of data collection organization and return to the Registry. This will help maintain the accuracy, timeliness and completeness of clinical data and also in parallel, support the career development of informatics staff.



   A7 The role of the Renal Registry for Trust managers
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(7.1) As the basis of the clinical governance initiative, the gathering and presentation of clinical data are regarded as essential parts of routine patient management in the health service.
(7.2) One of the principles of health service informatics is that the best data are acquired from clinical information recorded at the point of health care delivery.
(7.3) Renal services data entered on local systems by staff directly engaged with patients are likely to be of the highest quality and it is these that the Registry intends to capture.
(7.4) The Registry provides a cost-effective source of detailed information on renal services.
(7.5) The regular reports of the Registry supply details of patient demographics, treatment numbers, treatment quality and outcomes. Data are compared with both national standards and national performance, for benchmarking and quality assurance. The assessment of contract activity and service delivery is possible through these data returns, without the need for further costly Trust or commissioner administrative activity. These data should be particularly valuable to contracts managers and those responsible for clinical governance.
(7.6) Data are available on unit case mix, infrastructure and facilities.
(7.7) It is anticipated that data on patients with renal disease other than those requiring RRT will become available in time (CKD).
(7.8) It is anticipated that Trust interests may be served through the participation of a national Trust representative on the Registry Committee.



   A8 The role of the Renal Registry for commissioners of health care
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(8.1) The commissioners of health care include Regional Specialty Commissioning Groups, the networks or joint renal strategy groups supporting them and the Primary Care Trusts.
(8.2) The use of information sources such as the Registry is advised in the National Renal Review [6] in order to promote benchmarking and quality assurance of renal programmes. The comprehensive tracking of relatively small but costly renal cohorts should be regarded as a routine part of speciality case management.
(8.3) The Registry provides validated, comparative reports of renal unit activity on a regular basis to participating centres. These allow assessment of unit performance across a wide range of variables relating to structure, process and outcome measures.
(8.4) There are economies of scale in the performance of audit through the Registry, since multiple local audits are not required.
(8.5) The incidence of RRT treated locally, their mortality and renal transplant rates should also be of interest. The assessment of referral and treatment patterns of patients with established renal failure by postcode analysis indicates the geographical origin. This information also allows the expression of differences relating to geography, ethnicity and social deprivation. These data may also identify potential unmet need in the population and permit assessment on the equity of service provision. In the future, the Registry database should also provide information on nephrology and pre-dialysis patients (CKD). This will allow a prediction of the need for RRT facilities, as well as indicating the opportunities for beneficial intervention.
(8.6) Registry data are used to track patient acceptance and prevalence rates over time, which allows the modelling of future demand and the validation of these predictions.
(8.7) Information on the clinical diagnosis of new and existing RRT patients may help identify areas where possible preventive measures may have maximal effect.
(8.8) The higher acceptance rates in the elderly, and the increasing demand from ethnic groups due to a high prevalence of renal, circulatory and diabetic disease, are measurable.
(8.9) Comparative data are available in all categories for national and regional benchmarking.
(8.10) The Registry offers independent expertise in the analysis of renal services data and their interpretation, a resource that is widely required but difficult to otherwise obtain.
(8.11) The cost of supporting the Registry is £16 per registered patient per annum, which is less than 0.05% of the typical cost of a dialysis patient per annum. It is expected that this cost will need to be made explicit within the renal services contract.
(8.12) The Registry Committee includes a representative from the health care commissioners. This allow an influence on the development of the Registry and the topics of interest in data collection and analysis.



   A9 The role of the Renal Registry for national quality assurance agencies
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(9.1) The role of the Registry in the national quality assurance programme of the Healthcare Commission, will depend on the decisions on the role and responsibilities of that agency and their means to discharging them.
(9.2) The demographic, diagnostic and outcomes data could support the investigation of clinical effectiveness.
(9.3) The case mix information and comorbidity data that would allow better assessment of survival statistics remains incomplete. There is also some clinical scepticism whether ‘correction’ of outcome data would reflect the realities of clinical practice.
(9.4) With the publication of renal unit survival data, consideration of this issue in particular would be welcome in nephrological circles, with correspondence to the Registry Committee.



   A10 References
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

  1. http://www.kidney.org.uk/campaigns/Renal-nsf/pt1-nsf-content-report.pdf [Accessed 23 November 2005]
  2. http://www.kidney.org.uk/campaigns/Renal-nsf/nsf-pt2.pdf[Accessed 23 November 2005]
  3. RNSF IS 1 http://www.dh.gov.uk/assetRoot/04/07/79/25/04077925.pdf
  4. RNSF IS 2 http://www.dh.gov.uk/assetRoot/04/11/35/05/04113505.pdf
  5. Black N. Clinical governance: fine words or action? Br Med J 1998; 316: 297–298.
  6. Black N. High-quality clinical databases: breaking down barriers [Editorial]. Lancet 1999; 353: 1205–1206
  7. http://www.ukchip.org.uk/
  8. http://www.informatics.nhs.uk/cgi-bin/item.cgi?id=1506 [Accessed 23 November 2005]
  9. http://www.assist.org.uk/



   Appendix B—Definitions, statistical methodology and analysis criteria, B1 Definitions of analysis quarters
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

Quarter Dates

1 1 January–31 March
2 1 April–30 June
3 1 July–30 September
4 1 October–31 December

The quarterly biochemistry data were extracted from renal unit systems as the last data item stored for that quarter. If the patient treatment modality was haemodialysis (HD), the software will try to select a pre-dialysis value.



   B2 Renal Registry modality definitions
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
Home haemodialysis
Home HD patients cease to be classed as such if they need longer than 2 weeks of hospital dialysis when not an in-patient.

Satellite dialysis unit
A renal satellite unit is defined as an HD facility that is linked to a main renal unit and not autonomous for medical decisions, and that provides chronic outpatient maintenance HD but with no acute or inpatient nephrology beds on site.

Treatment modality at 90 days
This is used by the United States Renal Data System (USRDS) and is the modality that the patient is on at day 90 regardless of any changes from the start. It is a general indicator of initial dialysis but could miss failed continuous ambulatory peritoneal dialysis (CAPD). This would also miss patients intended for home HD who were not home yet. This modality is calculated by the Registry, which allows the definition to be changed.

Start of established renal failure
Established renal failure (also known as end-stage renal failure/end-stage renal disease) was defined as the date of the first dialysis (or of pre-emptive transplant).

If a patient started as ‘acute’ renal failure and did not recover, the date of start of renal replacement should have been backdated to the start of acute dialysis.

If a patient was started on dialysis and dialysis was temporarily stopped for less than 90 days for any reason (including access failure and awaiting the formation of further access) except the recovery of renal function, the date of the start of renal replacement therapy (RRT) remained the date of first dialysis. If the patient had stopped for longer than 90 days, he or she was classed as ‘recovered’.

Change of modality from PD to HD
Sites are requested to log in their timeline changes from peritoneal dialysis (PD) to HD if the modality switch is for longer than 30 days.

In analyses that included PD technique survival, patients on PD who changed to HD for less than 31days before changing back to PD were classified as remaining on PD. Those remaining on HD for more than 30 days and then changing back to PD were classified as having changed to HD.



   B3 Analysis criteria
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
Definition of the take-on population (Incidence)
The take-on population in a year included patients who later recovered from ERF after 90 days from the start of treatment. Patients newly transferred into a centre who were already on RRT were excluded from the take-on population for that centre. Patients restarting dialysis after a failed transplant were also excluded (unless they started RRT in that current year).

Since patients who restarted RRT after recovering from ERF were included in the take-on population, the following scenario can occur: a patient may start RRT in 2004, recover and then restart RRT in 2004. Such patients were counted twice in the analysis providing they had been receiving RRT for more than 90 days on each occasion.

Patients who started treatment at a centre and then transferred out soon after receiving treatment were counted at the original centre for all analyses of treatment on the 90th day.

Definition of the prevalent population
This was calculated as all patients who are alive on 31 December and included the incident cohort for that year alive on that date.

Confidence interval
The 95% confidence intervals have been calculated using the normal approximation of the Poisson.

Death rate calculation
The death rate per 100 patient years was calculated by counting the number of deaths and dividing by the person-years exposed. This includes all patients, including those who died within the first 3 months of therapy. The person-years at risk were calculated by adding up, for each patient, the number of days at risk (until they died or transferred out) and dividing by 365.

Odds ratio
The odds of dying was the:


Formula

The odds ratio was the:


Formula

Hazard function
The hazard function was the probability of dying in a short time interval considering survival to that interval.

Hazard ratio
The hazard ratio was the:


Formula

Relative hazard
Following the notation of Collett, D (2003)—Modelling Survival Data in Medical Research, Chapman & Hall, p57:


Formula

The relative hazard was the exp(ßxi) component in the general proportional hazards model with age, the variable of interest and it's square as covariates. The plots were done for exp(ßxi) for different values of the variable of interest only, in other words, age was taken as a constant value of zero.

Z-scores
The enquiry into the excess of paediatric cardiac deaths at the Bristol Royal Infirmary defined an outlier as lying beyond 3 SDs from the mean, using the statistical methodology of Shewhart's control theory. This analysis relied on the centre sizes and hence their SDs, being very similar. Renal units in the UK vary greatly in size, catchment populations varying from 300 000 to over 2 million. There was a consequent variation in the total patient number on RRT so the figure for the SDs will vary greatly between centres. The SDs for the total RRT population is not an appropriate number as this will be very small. Therefore, the Shewhart methodology cannot be applied. The Registry has used the accepted statistical technique of Z-scores to identify any outliers.

Definition
Z-scores are sometimes called ‘standard scores’. It is a measure of the distance in SDs of a sample from the mean.

The Z-score transformation is especially useful when seeking to compare the relative standings of items from distributions with different means and/or different SDs. The Z-score for an item indicates how far and in what direction, that item deviates from its distribution's mean, expressed in units of its distribution's SD.


Formula

The Z-score is therefore an adjustment for the size of the centre and when comparing the different Z-scores for all the centres, they should be normally distributed. The observed Z-value compared with the expected Z-value (see explanation subsequently) should be on a straight line.

Calculation of the expected Z-value
Suppose there is a normally distributed population from which random samples of some specific size, say 10 are repeatedly drawn. These 10 values from each such random sample are sorted into increasing order, smallest value to largest value. When the sample data is sorted in this way, the individual numbers are called order statistics. The smallest value will vary somewhat from one such sample to another, but over the long run, the smallest values should tend to cluster around some average smallest value and produce a mean or expected values of the order statistics. These data have been compiled into tables so that for every specific total number of ordered samples (e.g. 38 centres with Registry survival data) there is an expected Z-value for each ordered centre in that list.

Survival analyses of prevalent cohort
These analyses excluded the current year's incident cohort. Note some Renal Registries include these patients in the prevalent survival.

Criteria for analysis by treatment modality in a quarter
The following quarterly entries were included and excluded:

  • Patients on haemodialysis with a treatment centre of ‘elsewhere’ were removed. It should be noted that there were some patients on transplant with a treatment centre of ‘Elsewhere’; these patients were included.
  • Entries for which the hospital centre was not the primary treatment centre were removed from the analysis of data for that centre.
  • Patients who had been on RRT for less than 90 days were removed (by definition of ERF).

There were however, a few exceptions to these rules:

  1. If a patient's initial entry on the treatment timeline contained a ‘transferred in’ code, the patient was assumed to have been on RRT for longer than 90 days since the patient must have started RRT earlier than this elsewhere. Therefore, patients with an initial entry on the treatment timeline with a ‘transferred in’ code were included for all quarters. A patient with an initial treatment modality of ‘transferred in on 1 March 2005 would, for example, be included for the quarter 1,2005 even though the number of days on RRT would be calculated as 30 days.
  2. For patients who recovered renal function for a period of time and then went into ERF, the length of time on RRT was calculated from the day on which the patient restarted RRT. For a patient with an initial treatment start date of 1 March 2005 who recovered on the 1 June 2005 and then resumed RRT again on 1 November 2005, for example, the number of days on RRT would be calculated from 1 November 2005. The patient would be excluded from the analysis for quarter 4/05 since on 31 December 2005, he or she would have been on RRT for only 90 days. The patient would be included in the analysis from quarter 1/06 onwards.

If recovery was for less than 90 days, the start of RRT renal replacement therapy was calculated from the date of the first episode and the recovery period ignored. Patients who had transferred out or stopped treatment without recovery of function before the end of the quarter were excluded.

Criteria for analysis of biochemistry in a quarter
The analysis used information from the quarterly treatment table. In addition to the treatment modality criteria listed above, patients with the following quarterly entries were also excluded:

  1. Patients who had ‘transferred in’ to the centre in that particular quarter were excluded. If, for example, a patient transferred in on 1 March 2005, the patient was excluded from that biochemistry analysis of the centre transferred to in that quarter.
  2. Patients who had changed treatment modality in that particular quarter were excluded.

Treatment modality on day 90 of starting RRT
This was obtained from the treatment modality of the take-on population after 90 days of being on RRT. For this reason, patients who started treatment between 1 October 2004 and 31 September 2005 were used in this analysis.

The sample used was that defined by the take-on population.

Patients were counted at their take-on hospital centre rather than at their hospital centre on day 90. This is important as some patients had transferred out of their initial hospital centre by day 90.

Patients who died before they reached 90 days were excluded.

One-year survival of the take-on population
The sample used was the same as that defined for the take-on population except for recovered renal function patients, who were excluded.

Patients who transferred out of their initial treatment centre were censored on the day they transferred out if there was no further information in the timeline.

Analysis of 1-year survival of prevalent patients
The death rate within the year was calculated separately for the patients established on dialysis and with a functioning transplant on 1 January 2005. As there is an increased death rate in the first 3 months following transplantation, patients were included in the analysis only if they had not received a transplant between 1 October 2004 and 31 December 2004. The sample criteria thus became:

  1. Patients who had been receiving RRT for more than 90 days on 1 January 2005.
  2. Patients who had a transplant between 1 October 2004 and 31 December 2004 were excluded.
  3. Patients who transferred into a Registry centre were excluded if information was not available to confirm that they had not received a transplant between 1 October 2004 and 31 December 2004.
  4. The few patients who recovered renal function in 2005 were excluded.
  5. Patients who transferred out of a Registry centre to a non-Registry centre were censored at that date.
  6. A transplant patient whose transplant failed was censored at the time of restarting dialysis and dialysis patients who received a transplant were censored at the time of transplantation.
  7. Patients who died, received a transplant, or transferred out on 1 January 2005 were included and were counted as being at risk for 1 day.
  8. Patients who died on the day of the transplant were censored on this day rather than counted as a dialysis death.



   Appendix C—Renal services described for non-physicians
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
(Reproduced from the third edition of the Renal Association Standards document, August 2002).

This appendix provides information on the issues discussed in this Report, background information on renal failure and discusses the services available for its treatment.



   Renal diseases
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(1.1) Diseases of the kidney are not as common as cardiovascular conditions or cancers but are much more common than some well-known disorders such as multiple sclerosis or muscular dystrophy. Renal conditions account for about 7000 deaths per annum according to the Registrar General's figures, but these are probably an underestimate since about one-third of deaths of patients with renal failure are not recorded as such in mortality statistics. These figures exclude deaths from cancers of the kidney and associated organs of the urinary tract such as the bladder and prostate.
(1.2) Over 100 different diseases affect the kidneys. These diseases may present early with features such as pain, the presence of blood or protein in the urine, or peripheral oedema (swelling of the legs), but much renal disease is self-limiting; it occurs and heals with few or no symptoms or sequelae. On the other hand, some kidney diseases start insidiously and progress but are undetected until renal failure develops.



   Acute renal failure
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(1.3) Renal failure may be acute and reversible. It occurs in previously normal kidneys when their blood supply is compromised by a fall in blood pressure caused by crush injuries, major surgery, failure of the heart's pumping action, loss of blood, salt or water, or when they are damaged by poisons or overwhelming infection. Renal support is then needed for a few days or weeks before renal function returns. However, about half such patients die during these illnesses because of another condition, often the one which caused the renal failure.



   Chronic renal failure (CRF) and established renal failure (ERF)
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(1.4) More common is irreversible CRF, in which the kidneys are slowly destroyed over months or years. To begin with there is little to see or find and this means that many patients present for medical help very late in their disease, or even in the terminal stages. Tiredness, anaemia, a feeling of being ‘run down’ are often the only symptoms. However, if high blood pressure develops, as often happens when the kidneys fail, or is the prime cause of the kidney disease, it may cause headache, breathlessness and perhaps angina. Ankle swelling may occur if there is a considerable loss of protein in the urine.
(1.5) Progressive loss of kidney function is also called CRF. Early CRF is sometimes referred to as chronic renal impairment or insufficiency and ERF when it reaches its terminal stage. At this point, if nothing is done the patient will die. Two complementary forms of treatment—dialysis and renal transplantation are available and both are needed if ERF is to be treated.
(1.6) The incidence of chronic renal disease and ERF rises steeply with advancing age. Consequently, an increasing proportion of patients treated for ERF in this country are elderly and the proportion is even higher in some other developed countries. Evidence from the US suggests that the relative risk of ERF in the Black population (predominantly of African origin) is two to four times higher than that for Whites. Data collected during the review of renal specialist services in London suggest that there is in the Thames regions a similar greater risk of renal failure in certain ethnic populations (Asian and African-Caribbean) than in Whites, this is supported by national mortality statistics. People from the Indian subcontinent have a higher prevalence of non-insulin-dependent diabetes and those with diabetes are more likely than Whites to develop renal failure. This partly explains the higher acceptance rate of Asians onto renal replacement programmes.



   Causes of renal failure
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(1.7) Most renal diseases that cause renal failure fall into six categories.
(1) Systematic disease. Although many generalized diseases such as systematic lupus, vasculitis, amyloidosis and myelomatosis can cause kidney failure, by far the most important cause is diabetes mellitus (~20% of all renal disease in many countries). Progressive kidney damage may begin after some years of diabetes, particularly if the blood sugar and high blood pressure have been poorly controlled. Careful lifelong supervision of diabetes has a major impact in preventing kidney damage.
(2) Autoimmune disease. ‘Glomerulonephritis’ or ‘nephritis’ describes a group of diseases in which the glomeruli (the filters that start the process of urine formation) are damaged by the body's immunological response to tissue changes or infections elsewhere. Together, all forms of nephritis account for ~30% of renal failure in Britain. The most severe forms are therefore treated with medications that suppress response, but treatment makes only a small impact on the progress of this group of patients to ERF.
(3) High blood pressure. Severe (‘accelerated’) hypertension damages the kidneys, but the damage can be halted and to some extent reversed by early detection and early treatment of high blood pressure. This is a common cause of renal failure in patients of African origin.
(4) Obstruction. Anything that obstructs the free flow of urine can cause back-pressure on the kidneys. Much the commonest cause is enlargement of the prostate in elderly men.
(5) Infection of the urine. Cystitis is a very common condition, affecting about half of all women at some time in their lives, but it rarely has serious consequences. However, infections of the urine in young children or patients with obstruction, kidney stones or other abnormalities of the urinary tract may result in scarring of the kidney and eventual kidney failure.
(6) Genetic disease. One common disease, polycystic kidneys and many rare inherited diseases which affect the kidneys, account for about 8% of all kidney failure in Britain. Although present at birth, polycystic kidney disease often causes no symptoms until middle age or later. Understanding of its genetic basis is rapidly advancing and may lead to the development of effective treatment.



   Prevention
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(1.8) Although many diseases causing CRF cannot be prevented or arrested at present, better control of diabetes and high blood pressure and relief of obstruction have much to offer, provided they are employed early in the course of the disease before much renal damage has occurred. It has also been shown that a group of antihypertensives called angiotensin-converting enzyme inhibitors (ACEI) delay the progression of renal failure. Screening for renal disease has not been widely practised because the relatively low incidence of cases renders population screening inefficient and costly. Urine tests for protein or blood, or blood tests for the level of some substances normally excreted by the kidney such as creatinine and urea, are potentially useful methods for screening, if populations at risk of renal failure can be identified, e.g. diabetics and the elderly.



   Complications and comorbidity
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(1.9) Renal failure is often accompanied by other disease processes. Some are due to the primary disease, e.g. diabetes may cause blindness and diseases of the nerves and blood vessels. Others, such as anaemia, bone disease and heart failure, are consequences of the renal failure. Coincidental disease such as chronic bronchitis and arthritis are particularly common in older patients with renal failure. In addition, many patients with ERF have diseases affecting the heart and blood vessels (vascular) particularly ischaemic heart disease and peripheral vascular disease. All these conditions, collectively called comorbidity, can influence the choice of treatment for renal failure and may reduce its benefits. Expert assessment of the patient before ERF can reduce comorbidity and increase the benefit and cost-effectiveness of treatment. Thus, early detection and referral of patients at risk of renal failure is important.



   Renal replacement therapy
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(1.10) The term renal replacement therapy (RRT) is used to describe treatments for established renal failure in which, in the absence of kidney function, the removal of waste products from the body is achieved by dialysis and other kidney functions are supplemented by drugs. The term also covers the complete replacement of all kidney functions by transplantation.



   Therapeutic dialysis (‘renal dialysis’)
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(1.11) Dialysis involves the removal of waste products from the blood by allowing these products to diffuse across a thin membrane into dialysis fluid which is then discarded along with the toxic waste products. The fluid is chemically composed to draw or ‘attract’ excess salts and water from the blood to cross the membrane, without the blood itself being in contact with the fluid.



   Haemodialysis
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(1.12) The method first used to achieve dialysis was the artificial kidney, or haemodialysis. This involves the attachment of the patient's circulation to a machine through which fluid is passed and exchange can take place. A disadvantage of this method is that some form of permanent access to the circulation must be produced to be used at every treatment. Each session lasts 4–5 h and is needed three times a week.



   Peritoneal dialysis
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(1.13) The alternative is peritoneal dialysis, often carried out in the form of continuous ambulatory peritoneal dialysis (CAPD). In this technique, fluid is introduced into the peritoneal cavity (which lies around the bowel) for ~6 h before withdrawal. The washing fluid must be sterile in order to avoid peritonitis (infection and inflammation of the peritoneum), which is the main complication of the treatment. A silastic tube must be implanted into the peritoneum and this may give problems such as kinking and malposition. Each fluid exchange lasts 30–40 min and is repeated three or four times daily. Neither form of dialysis corrects the loss of the hormones secreted by the normal kidney so replacement with synthetic erythropoietin and vitamin D is often necessary.



   Renal transplantation
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(1.14) Renal transplantation replaces all the kidneys’ functions, so erythropoietin and vitamin D supplementation are unnecessary. A single kidney is placed, usually in the pelvis close to the bladder to which the ureter is connected. The kidney is attached to a nearby artery and vein. The immediate problem is the body's acute rejection of the foreign graft, which can largely be overcome during the first months using drugs such as steroids and cyclosporin. These drugs and others that can be used for that purpose, have many undesirable side effects, including the acceleration of vascular disease. This often means that myocardial infarcts and strokes are commoner in transplant patients than in age-matched controls. During subsequent years there is a steady loss of transplanted kidneys owing to a process of chronic rejection; treatment of this is quite unsatisfactory at the moment, so many patients require a second or even a third graft over several decades, with further periods of dialysis in between.
(1.15) The main problem with expanding the transplantation service is the shortage of suitable kidneys to transplant. Although the situation can be improved, it is now clear that whatever social and medical structures are present and whatever legislation is adopted, there will inevitably be a shortage of kidneys from humans. This remains the case even if kidneys from the newly dead (cadaver kidneys) are retrieved with the maximum efficiency and living donors (usually, but not always from close blood relatives of the recipient) are used wherever appropriate. Hope for the future rests with solving the problems of xenotransplantation (which involves using animal kidneys), probably from pigs, although baboons have also been suggested and are closer to humans. Many problems remain unsolved and it is thought highly unlikely that xenotransplantation will become a reliable treatment for ERF within the next 10 years.



   Nature of renal services
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 

(1.16) The work of a nephrologist includes the early detection and diagnosis of renal disease and the long-term management of its complications such as high blood pressure, anaemia and bone disease. The nephrologist may share the management with the general practitioner or local hospital physician and relies on them to refer patients early for initial diagnosis and specific treatment. At any one time, perhaps only 5% of patients under care are in-patients in wards, the remainder being treated in their homes with 20% of these attending the renal unit regularly for haemodialysis. However, in-patient nephrology and the care of patients receiving centre-based dialysis are specialized, complex and require experienced medical advice to be available on a 24 h basis. This implies sufficient staff to provide expert cover; cross-covering by inexperienced staff is inappropriate and to be condemned. The other 95% of renal work is sustained on an out-patient basis; this includes RRT by dialysis and the care of transplant patients.
(1.17) There are five major components to renal medicine.
(1) RRT: The most significant element of work relates to the preparation of patients in ERF for RRT and their medical supervision for the remainder of their lives. The patient population will present increasing challenges for renal staffing as more elderly and diabetic patients are accepted for treatment.
(2) Emergency work: The emergency work associated with the speciality consists of:
(i) Treatment of acute renal failure, often in volving multiple organ failure and acute-on-chronic renal failure. Close cooperation with other medical specialties, including intensive care, is therefore a vital component of this aspect of the service.
(ii) Management of medical emergencies arising from an ERF programme. This workload is bound to expand rapidly as the number, age and comorbidity of patients starting RRT increases and this may interrupt the regular care of patients already on RRT, so increased resources may be required.

(3) Routine nephrology: A substantial workload is associated with the immunological and metabolic nature of renal disease which requires investigative procedures in an in-patient setting. It is estimated that 10 in-patient beds per million of the population are required for this work.
(4) Investigation and management of fluid and electrolyte disorders: this makes up a variable proportion of the nephrologists work, depending on the other expertise available in the hospital.
(5) Out-patient work: the outpatient work in renal medicine consists of the majority of general nephrology together with clinics attended by dialysis and renal transplant patients.



   Further reading
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
Further details of renal services for renal failure, written for non-physicians, can be found in: Cameron JS. Kidney Failure – the Facts. London: Oxford University Press, 1996.



   Appendix D—Methodology of standardized acceptance rates calculation and administrative area geography in the UK and the analysis of data by PCT group for England
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
Chapter 3, on the incidence of new patients, includes an analysis of standardized acceptance rates in England, Wales, Scotland and Northern Ireland for areas covered by the Registry. The methodology is subsequently described. This methodology is also used in Chapter 4 and in this Appendix for analyses of prevalent patients.

Only some of the boundaries of Primary Care Trusts (PCTs) and Local Authorities (LAs) in England are similar. The Office for National Statistics (ONS) is in the process of re-aligning the PCT boundaries with those of LAs and hopes to complete this process by 2007. The data in this Report uses the PCT and LA boundaries from the 2001 census as the ONS have not issued new population tables for any of the changed boundaries.



   Patients
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
For acceptance rate analyses, all new cases recorded by the Registry as accepted on to RRT in each year were included. Each patient's postcode was matched to a 2001 Census output area. The analyses use the patient postcode rather than the GP postcode.



   Geography—Unitary Authorities, counties and other areas
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
In contrast to 2002, contiguous ‘county’ areas were not derived by merging Unitary Authorities (UAs) with a bordering county. For example, Southampton UA and Portsmouth UA were kept separate from Hampshire county. The final areas used were Metropolitan counties, Greater London districts, Welsh areas, Shire counties, UAs, Scottish Council areas and Northern Ireland District Council areas—these different types of area are collectively called ‘LA areas’ here.

Lists of areas as on 31 December 2000 were taken from http://www.statistics.gov.uk/geography/geographic_area_listings/administrative.asp



   Administrative area geography in England and Wales
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
There are currently 46 UAs in England, 34 shire counties and six metropolitan counties. Greater London forms a unique area type. Shire counties and Metropolitan counties are subdivided into districts; UAs are not subdivided. Greater London is subdivided into the London Boroughs and the City of London.

Unitary Authorities

Table D1. Unitary Authorities

Code UA name

00EB Hartlepool
00EC Middlesbrough
00EE Redcar and Cleveland
00EF Stockton-on-Tees
00EH Darlington
00ET Halton
00EU Warrington
00EX Blackburn with Darwen
00EY Blackpool
00FA Kingston upon Hull, City of
00FB East Riding of Yorkshire
00FC North East Lincolnshire
00FD North Lincolnshire
00FF York
00FK Derby
00FN Leicester
00FP Rutland
00FY Nottingham
00GA Herefordshire, County of
00GF Telford and Wrekin
00GL Stoke-on-Trent
00HA Bath and North East Somerset
00HB Bristol, City of
00HC North Somerset
00HD South Gloucestershire
00HG Plymouth
00HH Torbay
00HN Bournemouth
00HP Poole
00HX Swindon
00JA Peterborough
00KA Luton
00KF Southend-on-Sea
00KG Thurrock
00LC Medway
00MA Bracknell Forest
00MB West Berkshire
00MC Reading
00MD Slough
00ME Windsor and Maidenhead
00MF Wokingham
00MG Milton Keynes
00ML Brighton and Hove
00MR Portsmouth
00MS Southampton
00MW Isle of Wight

Shire counties
There are 34 shire counties, subdivided into non-metropolitan districts.


Table D2. Shire counties

Code County name

09 Bedfordshire
11 Buckinghamshire
12 Cambridgeshire
13 Cheshire
15 Cornwall and Isles of Scilly
16 Cumbria
17 Derbyshire
18 Devon
19 Dorset
20 Durham
21 East Sussex
22 Essex
23 Gloucestershire
24 Hampshire
26 Hertfordshire
29 Kent
30 Lancashire
31 Leicestershire
32 Lincolnshire
33 Norfolk
34 Northamptonshire
35 Northumberland
36 North Yorkshire
37 Nottinghamshire
38 Oxfordshire
39 Shropshire
40 Somerset
41 Staffordshire
42 Suffolk
43 Surrey
44 Warwickshire
45 West Sussex
46 Wiltshire
47 Worcestershire

Metropolitan counties
There are six metropolitan counties, all in England and representing heavily built-up areas (other than Greater London). These are subdivided into metropolitan districts.


Table D3. Metropolitan counties

Code Area name Metropolitan district

00BL Greater Manchester Bolton
00BM Bury
00BN Manchester
00BP Oldham
00BQ Rochdale
00BR Salford
00BS Stockport
00BT Tameside
00BU Trafford
00BW Wigan
00BX Cheshire and Merseyside Knowsley
00BY Liverpool
00CA Sefton
00BZ St Helens
00CB Wirral
00CC South Yorkshire Barnsley
00CE Doncaster
00CF Rotherham
00CG Sheffield
00CH Northumberland, Tyne and Wear Gateshead
00CJ Newcastle upon Tyne
00CK North Tyneside
00CL South Tyneside
00CM Sunderland
00CN West Midlands Birmingham
00CQ Coventry
00CR Dudley
00CS Sandwell
00CT Solihull
00CU Walsall
00CW Wolverhampton
00CX West Yorkshire Bradford
00CY Calderdale
00CZ Kirklees
00DA Leeds
00DB Wakefield

Greater London
This is an administrative unit covering the London metropolis. There are 32 boroughs and also the City of London (a City Corporation).


Table D4. London boroughs

Code Area name Borough name

00AA Greater London City of London
00AB Barking and Dagenham
00AC Barnet
00AD Bexley
00AE Brent
00AF Bromley
00AG Camden
00AH Croydon
00AJ Ealing
00AK Enfield
00AL Greenwich
00AM Hackney
00AN Hammersmith and Fulham
00AP Haringey
00AQ Harrow
00AR Havering
00AS Hillingdon
00AT Hounslow
00AU Islington
00AW Kensington and Chelsea
00AX Kingston upon Thames
00AY Lambeth
00AZ Lewisham
00BA Merton
00BB Newham
00BC Redbridge
00BD Richmond upon Thames
00BE Southwark
00BF Sutton
00BG Tower Hamlets
00BH Waltham Forest
00BJ Wandsworth
00BK Westminster

Welsh Unitary Authorities

Table D5. Welsh Unitary Authorities

Code Area name UA name

00PT Bro Taf Cardiff
00PH Merthyr Tydfil
00PF Rhondda; Cynon; Taff
00PD The Vale of Glamorgan
00NQ Dyfed Powys Ceredigion
00NU Carmarthenshire
00NS Pembrokeshire
00NN Powys
00PL Gwent Blaenau Gwent
00PK Caerphilly
00PP Monmouthshire
00PR Newport
00PM Torfaen
00PB Morgannwg Bridgend
00NZ Neath, Port Talbot
00NX Swansea
00NE North Wales Conwy
00NG Denbighshire
00NJ Flintshire
00NC Gwynedd
00NA Isle of Anglesey
00NL Wrexham

Scottish Council areas

Table D6. Scottish Council areas

00QA Aberdeen City
00QB Aberdeenshire
00QC Angus
00QD Argyll and Bute
00QE Scottish Borders
00QF Clackmannanshire
00QG West Dunbartonshire
00QH Dumfries and Galloway
00QJ Dundee City
00QK East Ayrshire
00QL East Dunbartonshire
00QM East Lothian
00QN East Renfrewshire
00QP Edinburgh, City of
00QQ Falkirk
00QR Fife
00QS Glasgow City
00QT Highland
00QU Inverclyde
00QW Midlothian
00QX Moray
00QY North Ayrshire
00QZ North Lanarkshire
00RA Orkney Islands
00RB Perth and Kinross
00RC Renfrewshire
00RD Shetland Islands
00RE South Ayrshire
00RF South Lanarkshire
00RG Stirling
00RH West Lothian
00RJ Eilean Siar

Northern Ireland District Council areas

Table D7. Northern Ireland District Council areas

95AA Antrim
95BB Ards
95CC Armagh
95DD Ballymena
95EE Ballymoney
95FF Banbridge
95GG Belfast
95HH Carrickfergus
95II Castlereagh
95JJ Coleraine
95KK Cookstown
95LL Craigavon
95MM Derry
95NN Down
95OO Dungannon
95PP Fermanagh
95QQ Larne
95RR Limavady
95SS Lisburn
95TT Magherafelt
95UU Moyle
95VV Newry and Mourne
95WW Newtownabbey
95XX North Down
95YY Omagh
95ZZ Strabane



   Areas included in Registry ‘covered’ population
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
All parts of Wales, Scotland and Northern Ireland are covered by the Registry but coverage is not yet complete for England. The Registry identified all areas in England which they estimated to have complete coverage and analysis was restricted to these areas.

The right hand column indicates whether the area has been included in the analyses. This is dependent on whether the renal unit in the area is sending data to the Registry and that there are no overlapping areas with renal units not yet connected to the Registry.
Table D8. Renal Registry coverage of England

UK area SHA Name Area type Code Covered in 2005?

North East County Durham and Tees Valley Darlington Unitary authority 00EH {checkmark}
Durham Shire county 20 {checkmark}
Hartlepool Unitary authority 00EB {checkmark}
Middlesbrough Unitary authority 00EC {checkmark}
Redcar and Cleveland Unitary authority 00EE {checkmark}
Stockton-on-Tees Unitary authority 00EF {checkmark}
Northumberland, Tyne and Wear Gateshead Metropolitan district 00CH {checkmark}
Newcastle upon Tyne Metropolitan district 00CJ {checkmark}
North Tyneside Metropolitan district 00CK {checkmark}
Northumberland Shire county 35 {checkmark}
South Tyneside Metropolitan district 00CL {checkmark}
Sunderland Metropolitan district 00CM {checkmark}
North West Cheshire and Merseyside Cheshire Shire county 13 {ballot}
Halton Unitary authority 00ET {checkmark}
Knowsley Metropolitan district 00BX {checkmark}
Liverpool Metropolitan district 00BY {checkmark}
Sefton Metropolitan district 00CA {checkmark}
St Helens Metropolitan district 00BZ {checkmark}
Warrington Unitary authority 00EU {checkmark}
Wirral Metropolitan district 00CB {checkmark}
Cumbria and Lancashire Blackburn with Darwen Unitary authority 00EX {checkmark}
Blackpool Unitary authority 00EY {checkmark}
Cumbria Shire county 16 {checkmark}
Lancashire Shire county 30 {checkmark}
Greater Manchester Bolton Metropolitan district 00BL {checkmark}
Bury Metropolitan district 00BM {checkmark}
Manchester Metropolitan district 00BN {ballot}
Oldham Metropolitan district 00BP {checkmark}
Rochdale Metropolitan district 00BQ {checkmark}
Salford Metropolitan district 00BR {checkmark}
Stockport Metropolitan district 00BS {ballot}
Tameside Metropolitan district 00BT {ballot}
Trafford Metropolitan district 00BU {ballot}
Wigan Metropolitan district 00BW {checkmark}
Yorkshire and the Humber North and East Yorkshire and Northern Lincolnshire East Riding of Yorkshire Unitary authority 00FB {checkmark}
Kingston upon Hull, City of Unitary authority 00FA {checkmark}
North East Lincolnshire Unitary authority 00FC {checkmark}
North Lincolnshire Unitary authority 00FD {checkmark}
North Yorkshire Shire county 36 {checkmark}
York Unitary authority 00FF {checkmark}
South Yorkshire Barnsley Metropolitan district 00CC {checkmark}
Doncaster Metropolitan district 00CE {checkmark}
Rotherham Metropolitan district 00CF {checkmark}
Sheffield Metropolitan district 00CG {checkmark}
West Yorkshire Bradford Metropolitan district 00CX {checkmark}
Calderdale Metropolitan district 00CY {checkmark}
Kirklees Metropolitan district 00CZ {checkmark}
Leeds Metropolitan district 00DA {checkmark}
Wakefield Metropolitan district 00DB {checkmark}
East Midlands Leicestershire, Northamptonshire and Rutland Leicester Unitary authority 00FN {checkmark}
Leicestershire Shire county 31 {checkmark}
Northamptonshire Shire county 34 {checkmark}
Rutland Unitary authority 00FP {checkmark}
Trent Derby Unitary authority 00FK {checkmark}
Derbyshire Shire county 17 {checkmark}
Lincolnshire Shire county 32 {checkmark}
Nottingham Unitary authority 00FY {checkmark}
Nottinghamshire Shire county 37 {checkmark}
West Midlands Birmingham and the Black Country Birmingham Metropolitan district 00CN {checkmark}
Dudley Metropolitan district 00CR {checkmark}
Sandwell Metropolitan district 00CS {checkmark}
Solihull Metropolitan district 00CT {checkmark}
Walsall Metropolitan district 00CU {checkmark}
Wolverhampton Metropolitan district 00CW {checkmark}
Coventry, Warwickshire, Herefordshire and Worcestershire Coventry Metropolitan district 00CQ {checkmark}
Herefordshire, County of Unitary authority 00GA {checkmark}
Warwickshire Shire county 44 {checkmark}
Worcestershire Shire county 47 {checkmark}
Shropshire and Staffordshire Shropshire Shire county 39 {checkmark}
Staffordshire Shire county 41 {ballot}
Stoke-on-Trent Unitary authority 00GL {ballot}
Telford and Wrekin Unitary authority 00GF {checkmark}
East of England Bedfordshire and Hertfordshire Bedfordshire Shire county 9 {checkmark}
Hertfordshire Shire county 26 {checkmark}
Luton Unitary authority 00KA {checkmark}
Essex Essex Shire county 22 {checkmark}
Southend-on-Sea Unitary authority 00KF {checkmark}
Thurrock Unitary authority 00KG {checkmark}
Norfolk, Suffolk and Cambridgeshire Cambridgeshire Shire county 12 {checkmark}
Norfolk Shire county 33 {checkmark}
Peterborough Unitary authority 00JA {checkmark}
Suffolk Shire county 42 {checkmark}
London North Central London Barnet London borough 00AC {checkmark}
Camden London borough 00AG {checkmark}
Enfield London borough 00AK {checkmark}
Haringey London borough 00AP {checkmark}
Islington London borough 00AU {checkmark}
North East London Barking and Dagenham London borough 00AB {checkmark}
City of London London borough 00AA {ballot}
Hackney London borough 00AM {checkmark}
Havering London borough 00AR {ballot}
Newham London borough 00BB {checkmark}
Redbridge London borough 00BC {checkmark}
Tower Hamlets London borough 00BG {checkmark}
Waltham Forest London borough 00BH {ballot}
North West London Brent London borough 00AE {ballot}
Ealing London borough 00AJ {checkmark}
Hammersmith and Fulham London borough 00AN {checkmark}
Harrow London borough 00AQ {ballot}
Hillingdon London borough 00AS {checkmark}
Hounslow London borough 00AT {checkmark}
Kensington and Chelsea London borough 00AW {ballot}
Westminster London borough 00BK {ballot}
South East London Bexley London borough 00AD {checkmark}
Bromley London borough 00AF {checkmark}
Greenwich London borough 00AL {checkmark}
Lambeth London borough 00AY {checkmark}
Lewisham London borough 00AZ {checkmark}
Southwark London borough 00BE {checkmark}
South West London Croydon London borough 00AH {checkmark}
Kingston upon Thames London borough 00AX {ballot}
Merton London borough 00BA {ballot}
Richmond upon Thames London borough 00BD {ballot}
Sutton London borough 00BF {ballot}
Wandsworth London borough 00BJ {ballot}
South East Hampshire and Isle of Wight Hampshire Shire county 24 {checkmark}
Isle of Wight Unitary authority 00MW {checkmark}
Portsmouth Unitary authority 00MR {checkmark}
Southampton Unitary authority 00MS {checkmark}
Kent and Medway Kent Shire county 29 {ballot}
Medway Unitary authority 00LC {ballot}
Surrey and Sussex Brighton and Hove Unitary authority 00ML {checkmark}
East Sussex Shire county 21 {checkmark}
Surrey Shire county 43 {checkmark}
West Sussex Shire county 45 {checkmark}
Thames Valley Bracknell Forest Unitary authority 00MA {checkmark}
Buckinghamshire Shire county 11 {checkmark}
Milton Keynes Unitary authority 00MG {checkmark}
Oxfordshire Shire county 38 {checkmark}
Reading Unitary authority 00MC {checkmark}
Slough Unitary authority 00MD {checkmark}
West Berkshire Unitary authority 00MB {checkmark}
Windsor and Maidenhead Unitary authority 00ME {ballot}
Wokingham Unitary authority 00MF {checkmark}
South West Avon, Gloucestershire and Wiltshire Bath and North East Somerset Unitary authority 00HA {checkmark}
Bristol, City of Unitary authority 00HB {checkmark}
Gloucestershire Shire county 23 {checkmark}
North Somerset Unitary authority 00HC {checkmark}
South Gloucestershire Unitary authority 00HD {checkmark}
Swindon Unitary authority 00HX {checkmark}
Wiltshire Shire county 46 {checkmark}
Dorset and Somerset Bournemouth Unitary authority 00HN {checkmark}
Dorset Shire county 19 {checkmark}
Poole Unitary authority 00HP {checkmark}
Somerset Shire county 40 {checkmark}
South West Peninsula Cornwall and Isles of Scilly Shire county 15 {checkmark}
Devon Shire county 18 {checkmark}
Plymouth Unitary authority 00HG {checkmark}
Torbay Unitary authority 00HH {checkmark}



   Population
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
The populations and age/gender breakdown for the LA areas were taken from Casweb. Casweb is a web interface to statistics and related information from the UK Census of Population, developed at Manchester University for academic use.



   Calculation of acceptance rates
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
Crude rate
The crude rate of acceptance on to RRT was calculated for each LA area for each year


Formula

Standardized acceptance rate ratio (SARR)
The age/gender standardized rate ratio of acceptance onto RRT was calculated for each LA area for each year:


Formula

Observed cases (Oi) were calculated by summing all cases in all age and gender bands for each LA area. Expected cases (Ei) for each LA area were calculated in the following way. For each age/gender band the observed acceptance rate over all LA areas (the standard population) was applied to the population of that LA in that age/gender band to determine the expected number of new cases. These expected numbers were summed over the age/gender bands to give an expected total number of cases in each LA area. The 95% confidence limits were calculated for each area.

A ratio of 1 indicates that the LA area's acceptance rate was as expected if the age/gender rates found in the total covered population applied to the LA area's population structure; a value above 1 indicates that the observed rate is greater than expected given the LA area's population structure, if the lower confidence limit was above 1 this is statistically significant at the 5% level. The converse applies to standardized rate ratios under one.

These rates have not been adjusted for ethnicity. Much higher rates are expected in populations with a high percentage of patients from South Asian and African Caribbean backgrounds.

A similar process was followed to give the prevalence rates by LA (in Chapter 4) and by Primary Care Trusts (PCT) (in this Appendix).



   Analysis of prevalent patients by PCT
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
Table D9 gives information on the observed and expected numbers of prevalent patients, the ratio of these (with confidence limits) and the crude rates per million population, by PCT in England. There are no PCTs in Scotland, Wales or Northern Ireland and the analyses of their data by LA are to be found in Chapters 3 and 4.

Groups such as PCTs, which represent relatively small populations of 30 000 to 250 000, often wish to assess their performance. When assessing a relatively infrequent occurrence such as prevalence of RRT in such small populations there are wide confidence intervals for any observed frequency. To enable assessment of whether an observed prevalence is likely to be significantly different from the national average, Figure D1 has been included in the report. From these, for any size of population (X-axis) the upper and lower 95% confidence limits around the national average prevalence (dotted lines) can be read from the Y-axis. Any observed prevalence for renal failure must be outside these limits for the given population to be statistically significantly different from the national average. Thus, for a population of 50 000 the observed prevalence would have to be outside the limits of 448 per million population to 904 per million population. However, for a population of 350 000 these limits are from 590 per million population to 762 per million population.
Table D9. Prevalent RRT patients by PCT

UK area SHA Name Code Tot exp Tot pop Tot obs O/E L 95% CL U 95% CL Crude rate pmp

North East County Durham and Tees Valley Darlington PCT 5J9 67.37 97 849 61 0.91 0.70 1.16 623.4
Derwentside PCT 5KA 60.04 85 171 64 1.07 0.83 1.36 751.4
Durham and Chester-le -Street PCT 5KC 95.48 140 644 85 0.89 0.72 1.10 604.4
Durham Dales PCT 5J8 61.71 85 531 60 0.97 0.75 1.25 701.5
Easington PCT 5KD 64.87 93 971 58 0.89 0.69 1.16 617.2
Hartlepool PCT 5D9 59.81 88 711 56 0.94 0.72 1.22 631.3
Langbaurgh PCT 5KN 68.58 97 028 73 1.06 0.85 1.34 752.4
Middlesbrough PCT 5KM 114.30 176 806 110 0.96 0.80 1.16 622.1
North Tees PCT 5E1 118.40 177 992 104 0.88 0.72 1.06 584.3
Sedgefield PCT 5KE 60.79 87 204 64 1.05 0.82 1.35 733.9
Northumberland, Tyne and Wear Gateshead PCT 5KF 133.52 191 133 131 0.98 0.83 1.16 685.4
Newcastle PCT 5D7 167.02 259 470 157 0.94 0.80 1.10 605.1
North Tyneside PCT 5D8 135.06 191 999 133 0.98 0.83 1.17 692.7
Northumberland Care Trust TAC 222.28 305 536 197 0.89 0.77 1.02 644.8
South Tyneside PCT 5KG 106.00 152 785 96 0.91 0.74 1.11 628.3
Sunderland Teaching PCT 5KL 188.12 280 805 182 0.97 0.84 1.12 648.1
North West Cheshire and Merseyside Bebington and West Wirral PCT 5F8 87.82 118 951 81 0.92 0.74 1.15 681.0
Birkenhead and Wallasey PCT 5H2 128.44 193 264 139 1.08 0.92 1.28 719.2
Central Cheshire PCT 5H4
Central Liverpool PCT 5HA 148.29 237 680 154 1.04 0.89 1.22 647.9
Cheshire West PCT 5H3 108.28 151 111 89 0.82 0.67 1.01 589.0
Eastern Cheshire PCT 5H5
Ellesmere Port and Neston PCT 5H6 56.21 81 580 60 1.07 0.83 1.37 735.5
Halton PCT 5J1 76.39 118 185 77 1.01 0.81 1.26 651.5
Knowsley PCT 5J4 96.12 150 494 109 1.13 0.94 1.37 724.3
North Liverpool PCT 5G9 64.60 102 529 71 1.10 0.87 1.39 692.5
South Liverpool PCT 5HC 66.76 98 107 82 1.23 0.99 1.53 835.8
South Sefton PCT 5M5 114.00 168 764 110 0.96 0.80 1.16 651.8
Southport and Formby PCT 5F9 85.21 114 120 59 0.69 0.54 0.89 517.0
St Helens PCT 5J3 120.17 176 810 98 0.82 0.67 0.99 554.3
Warrington PCT 5J2 127.13 190 391 106 0.83 0.69 1.01 556.7
Cumbria and Lancashire Blackburn With Darwen PCT 5CC 82.59 137 556 90 1.09 0.89 1.34 654.3
Blackpool PCT 5HP 102.88 142 184 70 0.68 0.54 0.86 492.3
Burnley, Pendle and Rossendale PCT 5G8 159.11 244 449 143 0.90 0.76 1.06 585.0
Carlisle and District PCT 5D4 80.65 113 582 62 0.77 0.60 0.99 545.9
Chorley and South Ribble PCT 5F2 139.53 203 189 82 0.59 0.47 0.73 403.6
Eden Valley PCT 5D5 51.95 69 020 45 0.87 0.65 1.16 652.0
Fylde PCT 5HE 55.72 72 657 31 0.56 0.39 0.79 426.7
Hyndburn and Ribble Valley PCT 5G7 84.08 124 672 75 0.89 0.71 1.12 601.6
Morecambe Bay PCT 5DD 217.73 308 189 137 0.63 0.53 0.74 444.5
Preston PCT 5HD 89.32 140 065 80 0.90 0.72 1.12 571.2
West Cumbria PCT 5D6 92.86 130 409 83 0.89 0.72 1.11 636.5
West Lancashire PCT 5F3 74.88 108 541 66 0.88 0.69 1.12 608.1
Wyre PCT 5HF 79.62 105 713 58 0.73 0.56 0.94 548.7
Greater Manchester Ashton, Leigh and Wigan PCT 5HG 202.20 301 207 134 0.66 0.56 0.78 444.9
Bolton PCT 5HQ 170.57 261 329 136 0.80 0.67 0.94 520.4
Bury PCT 5JX 119.41 180 637 54 0.45 0.35 0.59 298.9
Central Manchester PCT 5CL
Heywood and Middleton PCT 5F4
North Manchester PCT 5CR
Oldham PCT 5J5 138.84 217 456 69 0.50 0.39 0.63 317.3
Rochdale PCT 5JY 83.30 131 546 54 0.65 0.50 0.85 410.5
Salford PCT 5F5 141.82 215 817 88 0.62 0.50 0.76 407.8
South Manchester PCT 5AA
Stockport PCT 5F7
Tameside and Glossop PCT 5LH
Trafford North PCT 5F6
Trafford South PCT 5CX
Yorkshire and the Humber North and East Yorkshire and Northern Lincolnshire Craven, Harrogate and Rural District 5KJ 144.92 202 790 117 0.81 0.67 0.97 577.0
PCT
East Yorkshire PCT 5E3 121.68 169 845 101 0.83 0.68 1.01 594.7
Eastern Hull PCT 5E5 72.01 113 309 74 1.03 0.82 1.29 653.1
Hambleton and Richmondshire PCT 5KH 78.87 108 030 60 0.76 0.59 0.98 555.4
North East Lincolnshire PCT 5AN 106.82 159 214 110 1.03 0.85 1.24 690.9
North Lincolnshire PCT 5EF 104.77 148 965 94 0.90 0.73 1.10 631.0
Scarborough, Whitby and Ryedale PCT 5KK 118.52 157 007 94 0.79 0.65 0.97 598.7
Selby and York PCT 5E2 185.79 271 280 179 0.96 0.83 1.12 659.8
West Hull PCT 5E6 82.80 129 614 92 1.11 0.91 1.36 709.8
Yorkshire Wolds and Coast PCT 5E4 107.93 143 581 97 0.90 0.74 1.10 675.6
South Yorkshire Barnsley PCT 5JE 149.50 218 125 168 1.12 0.97 1.31 770.2
Doncaster Central PCT 5CK 47.55 70 401 58 1.22 0.94 1.58 823.8
Doncaster East PCT 5EK 77.27 110 122 66 0.85 0.67 1.09 599.3
Doncaster West PCT 5EL 70.78 104 970 70 0.99 0.78 1.25 666.9
North Sheffield PCT 5EE 75.45 117 114 101 1.34 1.10 1.63 862.4
Rotherham PCT 5H8 168.10 248 352 197 1.17 1.02 1.35 793.2
Sheffield South West PCT 5EP 84.70 124 598 60 0.71 0.55 0.91 481.5
Sheffield West PCT 5EN 68.63 107 094 71 1.03 0.82 1.31 663.0
South East Sheffield PCT 5EQ 110.52 164 239 125 1.13 0.95 1.35 761.1
West Yorkshire Airedale PCT 5AW 79.56 116 192 79 0.99 0.80 1.24 679.9
Bradford City PCT 5CF 69.32 135 189 139 2.01 1.70 2.37 1028.2
Bradford South and West PCT 5CG 84.11 132 310 103 1.22 1.01 1.49 778.5
Calderdale PCT 5J6 128.44 192 381 142 1.11 0.94 1.30 738.1
East Leeds PCT 5HK 105.71 162 757 114 1.08 0.90 1.30 700.4
Eastern Wakefield PCT 5E7 115.54 171 976 99 0.86 0.70 1.04 575.7
Huddersfield Central PCT 5LJ 89.75 137 821 113 1.26 1.05 1.51 819.9
Leeds North East PCT 5HJ 76.49 111 524 97 1.27 1.04 1.55 869.8
Leeds North West PCT 5HM 112.99 185 393 92 0.81 0.66 1.00 496.2
Leeds West PCT 5HH 70.70 108 892 84 1.19 0.96 1.47 771.4
North Bradford PCT 5CH 56.59 84 257 62 1.10 0.85 1.41 735.8
North Kirklees PCT 5J7 106.80 170 627 139 1.30 1.10 1.54 814.6
South Huddersfield PCT 5LK 54.93 80 460 45 0.82 0.61 1.10 559.3
South Leeds PCT 5HL 93.00 145 835 86 0.92 0.75 1.14 589.7
Wakefield West PCT 5E8 96.97 142 712 88 0.91 0.74 1.12 616.6
East Midlands Leicestershire, Northamptonshire and Rutland Charnwood and North West 5JC 155.60 230 214 149 0.96 0.82 1.12 647.2
Leicestershire PCT
Daventry and South Northamptonshire 5AC 68.82 101 006 55 0.80 0.61 1.04 544.5
PCT
Eastern Leicester PCT 5EY 103.41 173 316 206 1.99 1.74 2.28 1188.6
Hinckley and Bosworth PCT 5JA 80.08 115 004 77 0.96 0.77 1.20 669.5
Leicester City West PCT 5EJ 62.23 106 430 95 1.53 1.25 1.87 892.6
Melton, Rutland and Harborough PCT 5EH 98.21 137 726 93 0.95 0.77 1.16 675.3
Northampton PCT 5LW 133.19 208 645 131 0.98 0.83 1.17 627.9
Northamptonshire Heartlands PCT 5LV 189.77 283 758 168 0.89 0.76 1.03 592.1
South Leicestershire PCT 5JD 109.57 158 350 100 0.91 0.75 1.11 631.5
Trent Amber Valley PCT 5ED 82.29 116 564 81 0.98 0.79 1.22 694.9
Ashfield PCT 5FA 56.14 81 777 56 1.00 0.77 1.30 684.8
Bassetlaw PCT 5ET 75.31 107 327 66 0.88 0.69 1.12 614.9
Broxtowe and Hucknall PCT 5EV 95.15 136 951 98 1.03 0.84 1.26 715.6
Central Derby PCT 5AL 37.91 64 320 54 1.42 1.09 1.86 839.5
Chesterfield PCT 5EA 69.64 98 882 78 1.12 0.90 1.40 788.8
Derbyshire Dales and South Derbyshire PCT 5H7 74.47 107 461 61 0.82 0.64 1.05 567.6
East Lincolnshire PCT 5H9 205.57 265 403 173 0.84 0.73 0.98 651.8
Erewash PCT 5ER 74.81 110 123 65 0.87 0.68 1.11 590.2
Gedling PCT 5EC 79.19 111 795 82 1.04 0.83 1.29 733.5
Greater Derby PCT 5EX 106.84 157 342 116 1.09 0.91 1.30 737.2
High Peak and Dales PCT 5HN 73.23 100 153 21 0.29 0.19 0.44 209.7
Lincolnshire South West PCT 5D3 113.02 160 683 85 0.75 0.61 0.93 529.0
Mansfield District PCT 5AM 67.21 97 993 70 1.04 0.82 1.32 714.3
Newark and Sherwood PCT 5AP 75.13 105 709 91 1.21 0.99 1.49 860.9
North Eastern Derbyshire PCT 5EG 121.98 168 767 111 0.91 0.76 1.10 657.7
Nottingham City PCT 5EM 160.53 266 780 203 1.26 1.10 1.45 760.9
Rushcliffe PCT 5FC 73.23 105 507 62 0.85 0.66 1.09 587.6
West Lincolnshire PCT 5D2 151.61 217 042 141 0.93 0.79 1.10 649.6
West Midlands Birmingham and The Black Country Dudley Beacon and Castle PCT 5HV 76.54 112 378 80 1.05 0.84 1.30 711.9
Dudley South PCT 5HT 136.04 192 702 123 0.90 0.76 1.08 638.3
Eastern Birmingham PCT 5MY 125.91 203 367 202 1.60 1.40 1.84 993.3
Heart of Birmingham PCT 5MX 146.06 274 656 351 2.40 2.16 2.67 1278.0
North Birmingham PCT 5MW 102.06 150 593 138 1.35 1.14 1.60 916.4
Oldbury and Smethwick PCT 5MG 58.39 91 896 106 1.82 1.50 2.20 1153.5
Rowley, Regis and Tipton PCT 5MH 56.06 86 429 65 1.16 0.91 1.48 752.1
Solihull PCT 5D1 139.20 199 486 139 1.00 0.85 1.18 696.8
South Birmingham PCT 5M1 217.48 347 594 309 1.42 1.27 1.59 889.0
Walsall PCT 5M3 170.16 253 316 216 1.27 1.11 1.45 852.7
Wednesbury and West Bromwich PCT 5MJ 71.45 104 403 94 1.32 1.07 1.61 900.4
Wolverhampton City PCT 5MV 157.63 236 453 212 1.34 1.18 1.54 896.6
Coventry, Warwickshire, Herefordshire and Worcestershire Coventry PCT 5MD 190.63 300 667 231 1.21 1.07 1.38 768.3
Herefordshire PCT 5CN 128.06 174 133 113 0.88 0.73 1.06 648.9
North Warwickshire PCT 5MP 123.41 180 975 152 1.23 1.05 1.44 839.9
Redditch and Bromsgrove PCT 5MR 110.47 162 126 100 0.91 0.74 1.10 616.8
Rugby PCT 5M9 60.40 87 253 72 1.19 0.95 1.50 825.2
South Warwickshire PCT 5MQ 169.52 237 509 163 0.96 0.82 1.12 686.3
South Worcestershire PCT 5MT 197.31 277 881 169 0.86 0.74 1.00 608.2
Wyre Forest PCT 5DR 72.35 101 100 63 0.87 0.68 1.11 623.1
Shropshire and Staffordshire Burntwood, Lichfield and Tamworth 5DQ 101.88 151 448 113 1.11 0.92 1.33 746.1
PCT
Cannock Chase PCT 5MM 85.59 127 829 68 0.79 0.63 1.01 532.0
East Staffordshire PCT 5ML 76.79 112 718 71 0.92 0.73 1.17 629.9
Newcastle-Under-Lyme PCT 5HW
North Stoke PCT 5ME
Shropshire County PCT 5M2 202.68 279 717 184 0.91 0.79 1.05 657.8
South Stoke PCT 5MF
South Western Staffordshire PCT 5MN
Staffordshire Moorlands PCT 5HR
Telford and Wrekin PCT 5MK 99.95 158 142 86 0.86 0.70 1.06 543.8
East of England Bedfordshire and Hertfordshire Bedford PCT 5GD 96.96 147 829 94 0.97 0.79 1.19 635.9
Bedfordshire Heartlands PCT 5GE 154.80 232 867 137 0.89 0.75 1.05 588.3
Dacorum PCT 5GW 92.07 137 177 78 0.85 0.68 1.06 568.6
Hertsmere PCT 5CP
Luton PCT 5GC 110.41 184 294 144 1.30 1.11 1.54 781.4
North Hertfordshire and Stevenage PCT 5GH 118.07 179 745 123 1.04 0.87 1.24 684.3
Royston, Buntingford and Bishops Stortford PCT 5GK 39.95 61 985 27 0.68 0.46 0.99 435.6
South East Hertfordshire PCT 5GJ 114.95 171 365 107 0.93 0.77 1.13 624.4
St Albans and Harpenden PCT 5GX 86.86 129 128 54 0.62 0.48 0.81 418.2
Watford and Three Rivers PCT 5GV 106.06 161 527 27 0.25 0.17 0.37 167.2
Welwyn Hatfield PCT 5GG 65.78 97 551 54 0.82 0.63 1.07 553.6
Essex Basildon PCT 5GR 64.67 102 623 62 0.96 0.75 1.23 604.2
Billericay, Brentwood and Wickford PCT 5GP 93.15 131 718 78 0.84 0.67 1.05 592.2
Castle Point and Rochford PCT 5JP 118.62 165 218 99 0.83 0.69 1.02 599.2
Chelmsford PCT 5JN 90.92 133 719 71 0.78 0.62 0.99 531.0
Colchester PCT 5GM 102.34 155 376 76 0.74 0.59 0.93 489.1
Epping Forest PCT 5AJ 84.56 120 964 69 0.82 0.64 1.03 570.4
Harlow PCT 5DC 50.43 78 935 39 0.77 0.57 1.06 494.1
Maldon and South Chelmsford PCT 5GL 60.02 87 435 50 0.83 0.63 1.10 571.9
Southend On Sea PCT 5AK 109.82 160 344 113 1.03 0.86 1.24 704.7
Tendring PCT 5AH 108.08 136 487 85 0.79 0.64 0.97 622.8
Thurrock PCT 5GQ 90.01 143 212 92 1.02 0.83 1.25 642.4
Uttlesford PCT 5GN 49.61 70 928 41 0.83 0.61 1.12 578.0
Witham, Braintree and Halstead TAG 83.89 125 628 72 0.86 0.68 1.08 573.1
Norfolk, Suffolk and Cambridgeshire Broadland PCT 5JL 88.22 118 302 92 1.04 0.85 1.28 777.7
Cambridge City PCT 5JH 64.29 108 466 71 1.10 0.88 1.39 654.6
Central Suffolk PCT 5JT 71.73 97 953 54 0.75 0.58 0.98 551.3
East Cambridgeshire and Fenland PCT 5JK 97.47 136 129 76 0.78 0.62 0.98 558.3
Great Yarmouth PCT 5GT 66.30 90 889 20 0.30 0.19 0.47 220.0
Huntingdonshire PCT 5GF 93.33 140 111 98 1.05 0.86 1.28 699.4
Ipswich PCT 5JQ 94.43 141 672 92 0.97 0.79 1.20 649.4
North Norfolk PCT 5JM 79.68 97 168 90 1.13 0.92 1.39 926.2
North Peterborough PCT 5AF 62.11 99 239 72 1.16 0.92 1.46 725.5
Norwich PCT 5A2 78.30 121 145 71 0.91 0.72 1.14 586.1
South Cambridgeshire PCT 5JJ 89.55 129 562 73 0.82 0.65 1.03 563.4
South Peterborough PCT 5AG 58.00 86 912 65 1.12 0.88 1.43 747.9
Southern Norfolk PCT 5G1 147.72 200 492 134 0.91 0.77 1.07 668.4
Suffolk Coastal PCT 5JR 72.92 98 237 60 0.82 0.64 1.06 610.8
Suffolk West PCT 5JW 142.41 195 747 122 0.86 0.72 1.02 623.3
Waveney PCT 5JV 90.36 121 238 38 0.42 0.31 0.58 313.4
West Norfolk PCT 5CY 119.64 154 724 98 0.82 0.67 1.00 633.4
London North Central London Barnet PCT 5A9 197.03 314 203 223 1.13 0.99 1.29 709.7
Camden PCT 5K7 116.31 198 008 127 1.09 0.92 1.30 641.4
Enfield PCT 5C1 171.53 274 330 258 1.50 1.33 1.70 940.5
Haringey PCT 5C9 122.41 216 812 207 1.69 1.48 1.94 954.7
Islington PCT 5K8 101.96 175 798 140 1.37 1.16 1.62 796.4
North East London Barking and Dagenham PCT 5C2 99.24 164 344 102 1.03 0.85 1.25 620.6
Chingford, Wanstead and Woodford PCT 5C7
City and Hackney PCT 5C3 115.44 210 480 171 1.48 1.28 1.72 812.4
Havering PCT 5A4
Newham PCT 5C5 126.35 244 280 201 1.59 1.39 1.83 822.8
Redbridge PCT 5C8 109.24 176 883 365 3.34 3.02 3.70 2 063.5
Tower Hamlets PCT 5C4 102.24 196 567 130 1.27 1.07 1.51 661.4
Walthamstow, Leyton and Leytonstone PCT 5C6
North West London Brent PCT 5K5
Ealing PCT 5HX 182.26 301 433 273 1.50 1.33 1.69 905.7
Hammersmith and Fulham PCT 5H1 96.60 165 058 136 1.41 1.19 1.67 824.0
Harrow PCT 5K6
Hillingdon PCT 5AT 152.47 240 346 155 1.02 0.87 1.19 644.9
Hounslow PCT 5HY 127.74 212 397 209 1.64 1.43 1.87 984.0
Kensington and Chelsea PCT 5LA
Westminster PCT 5LC
South East London Bexley PCT TAK 145.65 218 675 160 1.10 0.94 1.28 731.7
Bromley PCT 5A7 201.27 295 865 188 0.93 0.81 1.08 635.4
Greenwich PCT 5A8 127.90 214 597 147 1.15 0.98 1.35 685.0
Lambeth PCT 5LD 147.96 266 487 207 1.40 1.22 1.60 776.8
Lewisham PCT 5LF 143.89 249 428 252 1.75 1.55 1.98 1 010.3
Southwark PCT 5LE 139.50 245 357 243 1.74 1.54 1.98 990.4
South West London Croydon PCT 5K9 206.21 331 406 252 1.22 1.08 1.38 760.4
Kingston PCT 5A5
Richmond and Twickenham PCT 5M6
Sutton and Merton PCT 5M7
Wandsworth PCT 5LG
South East Hampshire and Isle Of Wight East Hampshire PCT 5FD 120.90 168 691 100 0.83 0.68 1.01 592.8
Eastleigh and Test Valley South PCT 5LY 109.21 161 617 103 0.94 0.78 1.14 637.3
Fareham and Gosport PCT 5LX 124.88 180 116 113 0.90 0.75 1.09 627.4
Isle of Wight PCT 5DG 99.81 131 502 66 0.66 0.52 0.84 501.9
Mid-Hampshire PCT 5E9 117.17 169 042 81 0.69 0.56 0.86 479.2
New Forest PCT 5A1 129.35 168 914 83 0.64 0.52 0.80 491.4
North Hampshire PCT 5DF 135.61 206 226 104 0.77 0.63 0.93 504.3
Portsmouth City PCT 5FE 113.34 177 571 128 1.13 0.95 1.34 720.8
Blackwater Valley and Hart PCT 5G6 107.65 168 106 63 0.59 0.46 0.75 374.8
Southampton City PCT 5L1 133.88 217 329 119 0.89 0.74 1.06 547.6
Kent and Medway Ashford PCT 5LL
Canterbury and Coastal PCT 5LM
Dartford, Gravesham and Swanley PCT 5CM
East Kent Coastal PCT 5LN
Maidstone Weald PCT 5L2
Medway PCT 5L3
Shepway PCT 5LP
South West Kent PCT 5FF
Swale PCT 5L4
Surrey and Sussex Adur, Arun and Worthing PCT 5L8 159.47 216 387 135 0.85 0.72 1.00 623.9
Bexhill and Rother PCT 5FH 70.53 87 368 49 0.69 0.53 0.92 560.8
Brighton and Hove City PCT 5LQ 162.05 248 061 131 0.81 0.68 0.96 528.1
Crawley PCT 5MA 63.62 99 679 66 1.04 0.82 1.32 662.1
East Elmbridge and Mid Surrey PCT 5KP 184.63 260 806 143 0.77 0.66 0.91 548.3
East Surrey PCT 5KQ 109.23 159 808 78 0.71 0.57 0.89 488.1
Eastbourne Downs PCT 5LR 126.57 166 311 106 0.84 0.69 1.01 637.4
Guildford and Waverley PCT 5L5 152.85 222 319 81 0.53 0.43 0.66 364.3
Hastings and St Leonards PCT 5FJ 57.58 85 325 52 0.90 0.69 1.19 609.4
Horsham and Chanctonbury PCT 5MC 69.37 100 790 45 0.65 0.48 0.87 446.5
Mid-Sussex PCT 5FK 90.29 130 195 56 0.62 0.48 0.81 430.1
North Surrey PCT 5L6 139.23 199 554 139 1.00 0.85 1.18 696.6
Sussex Downs and Weald PCT 5LT 111.19 153 865 92 0.83 0.67 1.02 597.9
Western Sussex PCT 5L9 157.37 206 581 109 0.69 0.57 0.84 527.6
Woking PCT 5L7 134.13 199 939 121 0.90 0.75 1.08 605.2
Thames Valley Bracknell Forest PCT 5G2 65.79 108 151 56 0.85 0.66 1.11 517.8
Cherwell Vale PCT 5DV 81.73 122 009 82 1.00 0.81 1.25 672.1
Chiltern and South Buckinghamshire PCT 5G4 114.23 159 751 83 0.73 0.59 0.90 519.6
Milton Keynes PCT 5CQ 128.05 211 671 133 1.04 0.88 1.23 628.3
Newbury and Community PCT 5DK 61.44 93 090 59 0.96 0.74 1.24 633.8
North East Oxfordshire PCT 5DT 44.90 69 101 52 1.16 0.88 1.52 752.5
Oxford City PCT 5DW 93.50 154 597 96 1.03 0.84 1.25 621.0
Reading PCT 5DL 120.00 194 294 126 1.05 0.88 1.25 648.5
Slough PCT 5DM 70.38 119 059 118 1.68 1.40 2.01 991.1
South East Oxfordshire PCT 5DX 65.59 92 996 46 0.70 0.53 0.94 494.6
South West Oxfordshire PCT 5DY 128.12 190 520 147 1.15 0.98 1.35 771.6
Vale of Aylesbury PCT 5DP 115.92 176 322 150 1.29 1.10 1.52 850.7
Windsor, Ascot and Maidenhead PCT 5G3 96.25 143 891 76 0.79 0.63 0.99 528.2
Wokingham PCT 5DN 97.23 148 789 89 0.92 0.74 1.13 598.2
Wycombe PCT 5G5 86.79 134 621 86 0.99 0.80 1.22 638.8
South West Avon, Gloucestershire and Wiltshire Bath and North East Somerset PCT 5FL 117.01 168 857 104 0.89 0.73 1.08 615.9
Bristol North PCT 5JF 132.73 210 325 195 1.47 1.28 1.69 927.1
Bristol South and West PCT 5JG 106.35 170 088 127 1.19 1.00 1.42 746.7
Cheltenham and Tewkesbury PCT 5KW 107.87 156 444 91 0.84 0.69 1.04 581.7
Cotswold and Vale PCT 5KY 136.38 187 831 100 0.73 0.60 0.89 532.4
North Somerset PCT 5M8 137.95 188 787 148 1.07 0.91 1.26 784.0
Kennet and North Wiltshire PCT 5K4 130.76 191 978 93 0.71 0.58 0.87 484.4
South Gloucestershire PCT 5A3 164.41 244 909 181 1.10 0.95 1.27 739.1
South Wiltshire PCT 5DJ 79.42 111 984 50 0.63 0.48 0.83 446.5
Swindon PCT 5K3 118.73 183 706 110 0.93 0.77 1.12 598.8
West Gloucestershire PCT 5KX 148.62 218 086 172 1.16 1.00 1.34 788.7
West Wiltshire PCT 5DH 81.60 116 612 71 0.87 0.69 1.10 608.9
Dorset and Somerset Bournemouth PCT 5CE 101.52 147 140 76 0.75 0.60 0.94 516.5
Mendip PCT 5FX 74.15 106 714 70 0.94 0.75 1.19 656.0
North Dorset PCT 5CD 62.93 84 882 50 0.79 0.60 1.05 589.1
Poole PCT 5KV 129.62 177 766 104 0.80 0.66 0.97 585.0
Somerset Coast PCT 5FW 105.59 141 121 92 0.87 0.71 1.07 651.9
South and East Dorset PCT 5FN 120.14 146 810 88 0.73 0.59 0.90 599.4
South Somerset PCT 5K1 106.32 145 686 88 0.83 0.67 1.02 604.0
South West Dorset PCT 5FP 99.98 131 532 101 1.01 0.83 1.23 767.9
Taunton Deane PCT 5K2 72.19 101 955 70 0.97 0.77 1.23 686.6
South West Peninsula Central Cornwall PCT 5KT 136.82 184 265 152 1.11 0.95 1.30 824.9
East Devon PCT 5FT 94.51 117 674 60 0.63 0.49 0.82 509.9
Exeter PCT 5FR 86.49 130 206 86 0.99 0.80 1.23 660.5
Mid Devon PCT 5FV 67.84 92 204 74 1.09 0.87 1.37 802.6
North and East Cornwall PCT 5KR 117.74 156 064 130 1.10 0.93 1.31 833.0
North Devon PCT 5FQ 109.92 146 216 89 0.81 0.66 1.00 608.7
Plymouth PCT 5F1 156.29 234 266 164 1.05 0.90 1.22 700.1
South Hams and West Devon PCT 5CV 83.88 109 761 71 0.85 0.67 1.07 646.9
Teignbridge PCT 5FY 79.07 105 290 70 0.89 0.70 1.12 664.8
Torbay PCT 5CW 97.20 129 848 96 0.99 0.81 1.21 739.3
West of Cornwall PCT 5FM 117.01 156 156 113 0.97 0.80 1.16 723.6
Wales Bro Taf Cardiff 6A8 195.65 314 969 237 1.21 1.07 1.38 752.5
Merthyr Tydfil 6B8 37.02 55 566 59 1.59 1.23 2.06 1061.8
Rhondda, Cynon, Taff 6A9 149.52 223 693 203 1.36 1.18 1.56 907.5
Vale of Glamorgan 6C3 80.37 116 751 73 0.91 0.72 1.14 625.3
Dyfed Powys Carmarthenshire 6B7 126.36 172 960 141 1.12 0.95 1.32 815.2
Ceredigion 6A4 51.82 73 544 48 0.93 0.70 1.23 652.7
Pembrokeshire 6A3 84.83 115 618 80 0.94 0.76 1.17 691.9
Powys 6C4 93.55 125 503 87 0.93 0.75 1.15 693.2
Gwent Blaenau Gwent 6C2 46.66 68 272 57 1.22 0.94 1.58 834.9
Caerphilly 6B2 113.34 170 390 128 1.13 0.95 1.34 751.2
Monmouthshire 6A1 61.77 85 343 75 1.21 0.97 1.52 878.8
Newport 6B9 92.34 138 497 110 1.19 0.99 1.44 794.2
Torfaen 6B6 60.58 89 636 82 1.35 1.09 1.68 914.8
Morgannwg Bridgend 6B3 88.95 128 145 104 1.17 0.96 1.42 811.6
Neath Port Talbot 6A5 93.50 131 456 111 1.19 0.99 1.43 844.4
Swansea 6A6 156.70 226 286 205 1.31 1.14 1.50 905.9
North Wales Conwy 6A7 83.94 112 599 70 0.83 0.66 1.05 621.7
Denbighshire 6C1 66.61 92 531 70 1.05 0.83 1.33 756.5
Flintshire 6B5 101.30 148 393 108 1.07 0.88 1.29 727.8
Gwynedd 6A2 81.68 116 068 88 1.08 0.87 1.33 758.2
Isle of Anglesey 6B1 49.59 67 660 52 1.05 0.80 1.38 768.5
Wrexham 6B4 85.16 125 346 107 1.26 1.04 1.52 853.6

These are crude prevalence rates which have not been adjusted for age, sex or ethnicity. Much higher rates are expected in populations with a high percentage of patients from South Asian and African-Caribbean backgrounds.



   Appendix E—Data Tables
 Top
 Appendix A--The Renal Registry...
 A1 Executive summary
 A2 Introduction
 A3 Statement of intent
 A4 Relationships of the...
 A5 The role of...
 A6 The role of...
 A7 The role of...
 A8 The role of...
 A9 The role of...
 A10 References
 Appendix B--Definitions,...
 B2 Renal Registry modality...
 B3 Analysis criteria
 Appendix C--Renal services...
 Renal diseases
 Acute renal failure
 Chronic renal failure (CRF)...
 Causes of renal failure
 Prevention
 Complications and comorbidity
 Renal replacement therapy
 Therapeutic dialysis ('renal...
 Haemodialysis
 Peritoneal dialysis
 Renal transplantation
 Nature of renal services
 Further reading
 Appendix D--Methodology of...
 Patients
 Geography--Unitary Authorities,...
 Administrative area geography in...
 Areas included in Registry...
 Population
 Calculation of acceptance rates
 Analysis of prevalent patients...
 Appendix E--Data Tables
 Appendix G--Vascular Access and...
 Appendix H--laboratory...
 Appendix I--Abbreviations used...
 
E1 Patients starting renal replacement in 2005

Table E1.1. Take on figures for new patients on dialysis

Treatment centre Aged < 65

Aged > 65

% on HD % on PD % on HD % on PD

Abrdn 57 43 92 8
Airdrie 71 29 94 6
Antrim 58 42 86 14
B Heart 78 22 89 11
B QEH 66 34 78 22
Bangor 50 50 82 18
Basldn 53 47 75 25
Belfast 76 24 81 19
Bradfd 70 30 88 12
Brightn 59 41 80 20
Bristol 68 32 90 10
Camb 76 24 81 19
Cardff 70 30 88 13
Carlis 69 31 92 8
Carsh 69 31 84 16
Chelms 67 33 86 14
Clwyd 86 14 79 21
Covnt 62 38 78 22
D&Gall 60 40 75 25
Derby 50 50 72 28
Dorset 50 50 30 70
Dudley 44 56 73 27
Dundee 48 52 69 31
Dunfn 55 45 81 19
Edinb 67 33 90 10
Exeter 44 56 77 23
GlasRI 80 20 93 7
GlasWI 48 52 94 6
Glouc 54 46 84 16
Hull 59 41 87 13
Inverns 56 44 50 50
Ipswi 36 64 62 38
Klmarnk 35 65 94 6
L Barts 60 40 65 35
L Guys 82 18 91 9
L H&Cx