Skip Navigation


NDT Advance Access originally published online on April 3, 2007
Nephrology Dialysis Transplantation 2007 22(6):1789; doi:10.1093/ndt/gfm131
This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
22/6/1789    most recent
gfm131v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Cozzolino, M.
Right arrow Articles by Brancaccio, D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Cozzolino, M.
Right arrow Articles by Brancaccio, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Reply—Lanthanum hepatotoxicity-debate

Email: mariocozzolino{at}hotmail.com

Sir,

It was a great pleasure to receive Lacour and collaborators’ letter [1], and we are more than happy to continue the ‘lanthanum hepatotoxicity-debate’!

As we emphasized in our Editorial [2], which accompanied the paper by Ben-Dov and collaborators [3], the control of hyperphosphataemia in dialysis patients is one of the most important goals for nephrologists, to prevent both vascular calcification and secondary hyperparathyroidism (SHPT).

First, we described the different hypotheses of lanthanum carbonate and sevelamer hydrochloride on SHPT physiopathology, emphasizing that more studies need to be conducted, to clarify the direct role of a phosphate binder on either parathyroid gland growth or parathyroid hormone secretion. Second, we proposed a new definition instead of ‘lanthanum liver toxicity, accumulation or deposition’. Probably, we should consider ‘liver handling’. Unfortunately in their letter, Lacour and collaborators did not give enough attention to our editorial, in which we analysed all the ‘previous correspondence in Kidney International’.

In conclusion, the manuscript by Ben-Dov and collaborators confirmed that lanthanum deposited in uraemic rat liver, without increasing plasma transaminase levels, or causing any abnormalities in liver weight, liver magnetic resonance and light microscopy.

Conflict of interest statement. M.C. has received lecture honoraria from Shire, Genzyme, Abbott, Amgen, and Roche in the past.

Mario Cozzolino and Diego Brancaccio

Renal Division, S. Paolo Hospital
University of Milan

References

  1. Lacour B, Nikolov IG, Joki N, Drueke TB. Lanthanum carbonate, body lanthanum accumulation and potential liver toxicity. In: Nephrol Dial Transplant (2006–2007).
  2. Cozzolino M, Brancaccio D. Lanthanum carbonate—new data on parathyroid hormone control without liver damage. Nephrol Dial Transplant (2007) 22:316–318.[Free Full Text]
  3. Ben-Dov IZ, Pappo O, Sklair-Levy M, et al. Lanthanum carbonate decreases PTH gene expression with no hepatoxicity in uraemic rats. Nephrol Dial Transplant (2007) 22:362–368.[Abstract/Free Full Text]

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?



This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
22/6/1789    most recent
gfm131v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Cozzolino, M.
Right arrow Articles by Brancaccio, D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Cozzolino, M.
Right arrow Articles by Brancaccio, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?