Nephrology Dialysis Transplantation 2007 22(4):i; doi:10.1093/ndt/gfm140
© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
In this issue ...
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Adiponectin is an anti-atherogenic, anti-inflammatory and insulin-sensitizing adipokine
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Low plasma levels of adiponectin in CKD are associated with
increased risk of cardiovascular events. Some drugs, prominent
among these, thiazolidinediones, are able to raise the levels
but studies in CKD patients are lacking.
See Wieçek et al., pages 981–988
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Transitional nephrology
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This term covers the adolescent with renal disease and guides
this often difficult patient during the transition to adult
care. What the "adult nephrologist" should know about it.
See Bell pages 988–992
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The salt-sensitivity of hypertension is often not adequately treated
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In this paper, the mechanisms whereby renal sodium retention
causes essential hypertension are reviewed. Much has been learned
from a variety of genetic mutations and polymorphisms of sodium
channels and related proteins in the kidney resulting in the
dysregulation of the sodium metabolism and/or salt-sensitive
hypertension.
See Rodriguez-Iturbe and Vaziri, pages 992–996
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Hypoxia-induced loss of function peroxisome proliferator-activated receptor (PPAR)-
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Hypoxia reduces anti-inflammatory effects of PPAR-
activation
and may possibly modulate inflammatory responses in the diseased
kidney.
See Li et al., pages 1041–1052
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Ceravastatin, an HMG-CoA-reductase inhibitor prolongs lifespan of COL4A3 knockout mice, a model of Alport syndrome
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The functional, protective effects (delays in uraemia, reduction
in proteinuria) were associated with decreased renal fibrosis
and inflammation.
See Koepke et al., pages 1062–1070
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Glomerular expression of nephrin and synaptopodin is decreased in eclampsia
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This downregulation may be associated with the proteinuria seen
in preeclamptic women.
See Garovic et al., pages 1136–1144
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Peripheral arterial disease is common in dialysis patients
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Less invasive angioplasty (PTA) was successful in 97% of patients
with critical ischaemic limbs. This intervention should be preferred
to other more invasive interventions.
See Graziani et al., pages 1144–1150
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Adiponectin is an anti...
Transitional nephrology