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NDT Advance Access originally published online on February 3, 2007
Nephrology Dialysis Transplantation 2007 22(4):1267; doi:10.1093/ndt/gfm030
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© The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Lean body mass to estimate GFR

Email: giovanni.gambaro{at}univr.it

Sir,

The interesting paper by Taylor et al. [1] lends support to the idea that the variables used in the different formulas to estimate GFR (glomerular filtration rate) are surrogate markers of lean body mass. The following letter by Rigalleau et al. [2] did not fully confirm the findings, at least in diabetic patients.

We are rather puzzled by a part of the analysis conducted in the Taylor's paper however, i.e. it is not clear to us whether the GFR estimated by the new formula (including lean mass) and by the Cockcroft and Gault formula have been normalized in relation to body surface area. We feel that this is an important issue to consider for a proper comparison with measured GFR and the modification of diet in renal disease (MDRD) formulae, which express GFR values as ml/min/1.73 m2. It is also not clear why the authors did not match their data against the original, 6-variable MDRD formula. It would be interesting to know whether Taylor's results afford an improvement over the GFR measured or estimated by the Cockcroft and Gault formula, all after normalizing for body surface area, or the classical MDRD calculation.

Conflict of interest statement. None declared.

Mauro Negri, Mauro Zamboni and Giovanni Gambaro

Department of Biomedical and
Surgical Sciences
University of Verona, Italy

References

  1. Taylor TP, Wang W, Shrayyef MZ, Cheek D, Hutchison FN, Gadegbeku CA. (2006) Glomerular filtration rate can be accurately predicted using lean mass measured by dual-energy X-ray absorptiometry. Nephrol Dial Transplant 21:84–87.[Abstract/Free Full Text]
  2. Rigalleau V, Chauveau P, Lasseur C, et al. (2006) Glomerular filtration rate prediction using lean mass is unsuccessful in diabetic subjects. absorptiometry. Nephrol Dial Transplant 21:1143–1144.

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This Article
Right arrow Extract Freely available
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22/4/1267    most recent
gfm030v1
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