In this issue ...
In a lucid editorial comment, new insights into the pathogenesis and potential therapeutic targets of ADPKD are discussed.(See article by Ibraghimov-Beskrovnaya, pages 3367–3370).
An in-depth, beautifully illustrated editorial review updates the several anti-fibrotic therapeutic targets that at present have been investigated in different models of renal fibrosis.
(See article by Boor et al., pages 3391–3407).
Hypokalaemia is a multifactorial and usually hospital-acquired condition associated with hyponatraemia and hypomagnesaemia. One out of every six patients with hypokalaemia develops subsequent hyperkalaemia. Besides potassium suppletion, total parenteral nutrition (source of potassium), magnesium suppletion (may reduce kaliuresis) and haematological malignancy (may cause cell lysis) contribute to hyperkalaemia following hypokalaemia.
(See article by Crop et al., pages 3471–3477).
Thyroid disease is associated with ANCA small vessel vasculitis especially among women. A US population-based case-control study found that it was most frequently associated with the presence of MPO-ANCA.
(See article by Lionaki et al., pages 3508–3515).
Multiplexed screening of pro-inflammatory, anti-inflammatory, angiogenic, metabolic and anti-fibrinolytic factors revealed that IL-6, MMP-9, tPAI-1 and VEGF showed tight correlations with carotid atherosclerotic burden in patients with CKD.
(See article by Addabbo et al., pages 3521–3526).
Pulse wave velocity (pwv) is associated with cardiovascular disease in predialysis patients. In addition, traditional risk factors for cardiovascular disease were the main determinants of PWV.
(See article by Lemos et al., pages 3527–3532).
All double lumen dialysis catheters that were tested show a substantial amount of leak even when the catheter ‘lock’ volumes were used, and leak ratio increases significantly with 20% overfill. There is a leak even when using 20% less ‘lock’ volume. The amount of leak can be clinically important and may explain the reports of bleeding episodes after heparin lock and antibiotic toxicity after antibiotic and anticoagulant combination lock.
(See article by Sungur et al., pages 3533–3537).
A recent DOPPS analysis suggests that a single question about lack of appetite helps to identify haemodialysis patients with poorer nutritional status, inflammation, depression, and higher risks of hospitalization and death. This study also calls attention to a possible beneficial effect of longer haemodialysis on appetite.
(See article by Lopes et al., pages 3538–3546).
Stable maintenance haemodialysis patients have similar resting energy expenditure (REE) to healthy controls, and the dialysis procedure per se does not increase REE. Body temperature elevation during routine dialysis may rather be due to decreased heat removal. With the use of monitoring, body temperature can be kept stable (isothermic HD), which requires active cooling. This negative energy transfer is proportional to a decrease in blood volume induced by ultrafiltration.
(See article by Horá
ek et al., pages 3553–3560).
Systemic lupus erythematosus as a cause of ESRD in renal transplant recipients is associated with worse allograft and recipient survival compared to diabetes mellitus; this association is true for the entire population and for the recipients of a deceased donor (but not living donor) transplant. Deceased donor allograft recipients have worse outcomes compared with living allograft recipients.
(See article by Chelamcharla et al., pages 3623–3630).
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Related articles in NDT:
- Molecular pathogenesis of ADPKD and development of targeted therapeutic options
- Oxana Ibraghimov-Beskrovnaya
NDT 2007 22: 3367-3370.[Extract] [FREE Full Text] - Treatment targets in renal fibrosis
- Peter Boor, Katarína Sebeková, Tammo Ostendorf, and Jürgen Floege
NDT 2007 22: 3391-3407.[Extract] [FREE Full Text] - Hypokalaemia and subsequent hyperkalaemia in hospitalized patients
- Meindert J. Crop, Ewout J. Hoorn, Jan Lindemans, and Robert Zietse
NDT 2007 22: 3471-3477.[Abstract] [FREE Full Text] - Association between thyroid disease and its treatment with ANCA small-vessel vasculitis: a case–control study
- Sofia Lionaki, Susan L. Hogan, Ronald J. Falk, Melanie S. Joy, Hyunsook Chin, Caroline E. Jennette, J. Charles Jennette, and Patrick H. Nachman
NDT 2007 22: 3508-3515.[Abstract] [FREE Full Text] - Searching for biomarker patterns characterizing carotid atherosclerotic burden in patients with reduced renal function
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- Marcelo M. Lemos, Alessandra D. B. Jancikic, Fabiana M. R. Sanches, Dejaldo M. Christofalo, Sérgio A. Ajzen, Márcio H. Miname, Raul D. Santos, Fernando C. Fachini, Aluízio B. Carvalho, Sérgio A. Draibe, and Maria Eugênia F. Canziani
NDT 2007 22: 3527-3532.[Abstract] [FREE Full Text] - Exit of catheter lock solutions from double lumen acute haemodialysis catheters—an in vitro study
- Murat Sungur, Emel Eryuksel, Sinan Yavas, Azra Bihorac, A. Joseph Layon, and Lawrence Caruso
NDT 2007 22: 3533-3537.[Abstract] [FREE Full Text] - Lack of appetite in haemodialysis patients—associations with patient characteristics, indicators of nutritional status and outcomes in the international DOPPS
- Antonio Alberto Lopes, Stacey J. Elder, Nancy Ginsberg, Vittorio E. Andreucci, José Miguel Cruz, Shunichi Fukuhara, Donna L. Mapes, Akira Saito, Ronald L. Pisoni, Rajiv Saran, and Friedrich K. Port
NDT 2007 22: 3538-3546.[Abstract] [FREE Full Text] - Resting energy expenditure and thermal balance during isothermic and thermoneutral haemodialysis—heat production does not explain increased body temperature during haemodialysis
- Jirí Horácek, Sylvie Dusilová Sulková, Magdalena Fortová, Frantisek Lopot, Marta Kalousová, Lubos Sobotka, Jirí Chaloupka, Vladimír Tesar, Ales Zák, and Tomás Zima
NDT 2007 22: 3553-3560.[Abstract] [FREE Full Text] - The outcome of renal transplantation among systemic lupus erythematosus patients
- Madhukar Chelamcharla, Basit Javaid, Bradley C. Baird, and Alexander S. Goldfarb-Rumyantzev
NDT 2007 22: 3623-3630.[Abstract] [FREE Full Text]
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