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Nephrogenic systemic fibrosis is probably more prevalent than we think and needs a multidisciplinary approach. Besides gadodiamide exposure, high-dose epoietin β and higher serum levels of calcium and phosphate were associated with a higher risk of this condition in dialysis patients.(See editorial comment by Nortier and del Marmol, pages 3097–3101 and original articles by Marckmann et al., pages 3174–3178 and Othersen et al., pages 3179–3185)
Multiple factors play a role in the development of salt-sensitive hypertension in metabolic syndrome, including insulin resistance, angiotensin II, the "hormonal" role of the adipocyte, and salt and potassium dietary intake.
(See editorial comment by Fujita, pages 3102–3107)
Neointimal hyperplasia is a very common cause of graft stenosis. In these elegant animal experiments, early invasion of adventitial fibroblasts which transformed into myofibroblasts was observed. These cells start proliferation within hours after graft placement.
(See article by Li et al., pages 3139–3146)
TGF-β1 plays a central role in the inflammatory and fibrotic responses in diabetic nephropathy. Combined research in Canadian and Australian laboratories demonstrated that high glucose increases macrophage inflammatory protein-3
through a TGF-β1-dependent pathway in an in vitro model of human proximal tubular cells.
(See article by Qi et al., pages 3147–3153)
Phenylacetic acid, a newly defined uraemic toxin, affects osteoblastic functions such as proliferation, differentiation, mineralization, and responsiveness to PTH. This molecule could thus play a role in the pathogenesis of low bone turnover disease in CKD.
(See article by Yano et al., pages 3160–3165)
The prevalence and extent of coronary (CAC) and peripheral artery calcifications (PAC) were investigated in subjects with CKD, stages 3 and 4, by multi-slice computed tomography, and plain foot radiography, respectively. There was a 76% prevalence of CAC with and 46.5% without diabetes. PAC detected by foot radiography was not an adequate alternative screening marker for identifying CAC in this population.
(See article by Porter et al., pages 3208–3213)
Case-mix factors associated with choice of dialysis modality and 2-year survival were studied in patients aged 75 years or older in France. Overall, 18% started with peritoneal dialysis (PD), 50% with planned haemodialysis (HD) and 32% started with HD on an emergency basis. Not unexpectedly, unplanned HD was associated with a 50% higher risk of mortality and PD with a 30% higher risk compared with planned HD, independent of patient case-mix.
(See article by Couchoud et al., pages 3246–3254)
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Related articles in NDT:
- Nephrogenic systemic fibrosis—the need for a multidisciplinary approach
- Joëlle L. Nortier and Véronique del Marmol
NDT 2007 22: 3097-3101.[Extract] [FREE Full Text] - Insulin resistance and salt-sensitive hypertension in metabolic syndrome
- Toshiro Fujita
NDT 2007 22: 3102-3107.[Extract] [FREE Full Text] - Cellular and morphological changes during neointimal hyperplasia development in a porcine arteriovenous graft model
- Li Li, Christi M. Terry, Donald K. Blumenthal, Tadashi Kuji, Takahisa Masaki, Bonnie C. H. Kwan, Ilya Zhuplatov, John K. Leypoldt, and Alfred K. Cheung
NDT 2007 22: 3139-3146.[Abstract] [FREE Full Text] - High glucose induces macrophage inflammatory protein-3 in renal proximal tubule cells via a transforming growth factor-ß1 dependent mechanism
- Weier Qi, Xinming Chen, Yuan Zhang, John Holian, Ellein Mreich, Richard E. Gilbert, Darren J. Kelly, and Carol A. Pollock
NDT 2007 22: 3147-3153.[Abstract] [FREE Full Text] - The uraemic toxin phenylacetic acid inhibits osteoblastic proliferation and differentiation: an implication for the pathogenesis of low turnover bone in chronic renal failure
- Shozo Yano, Toru Yamaguchi, Ippei Kanazawa, Noriko Ogawa, Kumi Hayashi, Mika Yamauchi, and Toshitsugu Sugimoto
NDT 2007 22: 3160-3165.[Abstract] [FREE Full Text] - Case-control study of gadodiamide-related nephrogenic systemic fibrosis
- Peter Marckmann, Lone Skov, Kristian Rossen, James Goya Heaf, and Henrik S. Thomsen
NDT 2007 22: 3174-3178.[Abstract] [FREE Full Text] - Detection of coronary and peripheral artery calcification in patients with chronic kidney disease stages 3 and 4, with and without diabetes
- Christine J. Porter, Aristeidis Stavroulopoulos, Simon D. Roe, Kate Pointon, and Michael J.D. Cassidy
NDT 2007 22: 3208-3213.[Abstract] [FREE Full Text] - Associations between comorbidities, treatment choice and outcome in the elderly with end-stage renal disease
- Cécile Couchoud, Olivier Moranne, Luc Frimat, Michel Labeeuw, Vincent Allot, and Bénédicte Stengel
NDT 2007 22: 3246-3254.[Abstract] [FREE Full Text]
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