Skip Navigation


NDT Advance Access originally published online on February 27, 2006
Nephrology Dialysis Transplantation 2006 21(7):2036; doi:10.1093/ndt/gfl052
This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/7/2036    most recent
gfl052v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Sepe, V.
Right arrow Articles by Canton, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sepe, V.
Right arrow Articles by Canton, A. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author [2006]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Letter

High-dose folic acid supplements and responsiveness to rHu-EPO in HD patients

Email: vsepe{at}libero.it

Sir,

Schiffl and Lang [1] demonstrated that high-dose supplements of folic acid in elderly maintenance haemodialysis (HD) patients with normocytic anaemia have no effect on rHu-EPO (recombinant human erythropoietin) responsiveness. We can show data on 20 HD patients without macrocytic anaemia (F = 5, M = 15; age 74±13 years; dialysis age 93±95 months) supplemented with high-dose calcium levofolinate (Fol). Fol (25 mg) was administrated orally to all 20 HD patients at the end of each HD session for 6 months. All patients received weekly thrice HD using synthetic high-flux membranes, always reaching a Kt/v >1.2. Active bleeding, haemolysis or myeloproliferative disease was never observed during the follow-up. Data on Fol, haemoglobin (Hb) plasma levels and weekly i.v. rHu-EPO dosage are summarized in Table 1 as mean±SD. Our results confirm the data published by Schiffl and Lang [1], where high-dose Fol supplements do not influence the response to rHu-EPO in normocytic HD patients.


View this table:
[in this window]
[in a new window]
  		Table 1. Laboratory findings on 20 HD patients after 6 months of high-dose (25 mg) Fol supplementation

 
Conflict of interest statement. None declared.

Vincenzo Sepe, Gabriella Adamo, Maria Grazia Giuliano, Grazia Soccio, Carmelo Libetta and Antonio Dal Canton

Unit of Nephrology Dialysis and Transplantation IRCCS Policlinico San Matteo and University of Pavia Pavia Italy

References

  1. Schiffl H, Lang MS. Folic acid deficiency modifies the haematopoietic response to recombinant human erythropoietin in maintenance dialysis patients. Nephrol Dial Transplant 2006; 21: 133–137[Abstract/Free Full Text]

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. Mizuno, Y. Ito, N. Hepburn, T. Mizuno, Y. Noda, Y. Yuzawa, C. L. Harris, B. P. Morgan, and S. Matsuo
Zymosan, but Not Lipopolysaccharide, Triggers Severe and Progressive Peritoneal Injury Accompanied by Complement Activation in a Rat Peritonitis Model
J. Immunol., July 15, 2009; 183(2): 1403 - 1412.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
M. Desnos-Ollivier, M. Ragon, V. Robert, D. Raoux, J.-C. Gantier, and F. Dromer
Debaryomyces hansenii (Candida famata), a Rare Human Fungal Pathogen Often Misidentified as Pichia guilliermondii (Candida guilliermondii)
J. Clin. Microbiol., October 1, 2008; 46(10): 3237 - 3242.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/7/2036    most recent
gfl052v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Sepe, V.
Right arrow Articles by Canton, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sepe, V.
Right arrow Articles by Canton, A. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?