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NDT Advance Access originally published online on November 1, 2005
Nephrology Dialysis Transplantation 2006 21(3):819; doi:10.1093/ndt/gfi240
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Letters and Replies

The role of gender in estimating glomerular filtration rate

Karl Lhotta

Clinical Nephrology Division Innsbruck University Hospital Innsbruck, Austria

Email: Karl.Lhotta{at}uibk.ac.at

Sir,

In a recent article, Chung and colleagues [1] report that alcohol consumption is associated with higher glomerular filtration rate (GFR), as estimated by the Cockcroft–Gault and Modification of Diet in Renal Disease (MDRD) formulas. According to their data, non-alcohol users and alcohol users had identical age, serum creatinine and body mass index (BMI) (and, therefore, body weight). Albumin and urea, both factors in the MDRD formula, are not reported. Given these data, the only other factor that can cause a difference in estimated GFR is gender (quantified by a factor of 0.85 in the Cockcroft–Gault and 0.762 in the MDRD formula for women). The ratio of men to women is 229/464 in the non-alcohol users as compared with 215/221 in the alcohol users. Therefore, it is possible that the higher estimated GFR (eGFR) found in alcohol users is caused mainly by the higher proportion of men in that group compared with non-alcohol users. For clarity, I suggest that the authors report eGFR levels for men and women separately.

Conflict of interest statement. None declared.



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  1. Chung FM, Yang YH, Shieh TY, Shin SJ, Tsai JCR, Lee YJ. Effect of alcohol consumption on estimated glomerular filtration rate and creatinine clearance rate. Nephrol Dial Transplant 2005; 20: 1610–1616[Abstract/Free Full Text]

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This Article
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