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NDT Advance Access originally published online on April 26, 2005
Nephrology Dialysis Transplantation 2005 20(6):1271; doi:10.1093/ndt/gfh850
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© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

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Sir,

We thank Hussein and colleagues for their comments regarding our publication. We agree with them; there was a significant association between troponin I and coronary artery calcification, not only in the three patients with troponin I elevated above the cut-off level for the reference range (>0.5 ng/ml), but in the entire group of 14 patients with detectable troponin I (≥0.1 ng/ml), including those with troponin I below the cut-off level. The data for troponin I, compared to troponin T, are thought to be less consistent and are more difficult to interpret, since no standardization between assays using different antibodies exists [1,2]. In addition, the ‘detectable troponin I levels’ can vary with the method used to measure troponin I concentrations. Clearly, larger studies using more sensitive, standardized methods are required to determine the troponin I level of prognostic significance, which is associated with an increased severity of cardiovascular disease, including coronary artery calcification.

Hae Hyuk Jung

Department of Internal Medicine Kangwon National University Hospital Hyoja-3-dong 17-1 Chunchon 200-093 Republic of Korea Email: haehyuk{at}kangwon.ac.kr

References

  1. Panteghini M, Pagani F, Yeo KT et al. Committee on Standardization of Markers of Cardiac Damage of the IFCC. Evaluation of imprecision for cardiac troponin assays at low-range concentrations. Clin Chem 2004; 50: 327–332[Abstract/Free Full Text]
  2. Panteghini M. Performance of today's cardiac troponin assays and tomorrow's. Clin Chem 2002; 48: 809–810[Free Full Text]

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This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
20/6/1271-a    most recent
gfh850v1
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